Single cell transcriptomes reveal expression patterns of chemoreceptor genes

immusol

Melting dsDNA Donor Molecules Vastly Improves Precision Genome Enhancing in Caenorhabditiselegans

CRISPR genome modifying has revolutionized genetics in quite a few organisms. Contained in the nematode Caenorhabditiselegans one injection into every of the 2 gonad arms of an grownup hermaphrodite exposes tons of of meiotic germ cells to modifying mixtures, allowing the restoration of quite a lot of indels or small precision edits from every successfully injected animal. Sadly, significantly for extended insertions, modifying efficiencies can differ broadly, necessitating quite a lot of injections, and usually requiring co-selection methods.

Correct proper right here we present that melting double stranded DNA (dsDNA) donor molecules earlier to injection will enhance the frequency of tangible homology-directed restore (HDR) by quite a lot of fold for longer edits.

We describe troubleshooting methods that allow persistently excessive modifying efficiencies ensuing, as an illustration, in as lots as 100 unbiased GFP knock-ins from a single injected animal. These efficiencies make C. elegans by far the most effective metazoan to genome edit, eradicating limitations to the use and adoption of this facile system as a mannequin for understanding animal biology.

An embedded gene choice methodology utilizing knockoffs optimizing neural community

 Background: Gene alternative refers to find a small subset of discriminant genes from the gene expression profiles. The way in which to decide on genes that affect specific phenotypic traits efficiently is a crucial evaluation work throughout the topic of biology. The neural neighborhood has greater changing into functionality when dealing with nonlinear data, and it’ll most likely seize choices robotically and flexibly. On this work, we recommend an embedded gene alternative methodology using neural neighborhood.

The important genes could also be obtained by calculating the burden coefficient after the teaching is completed. In an effort to treatment the problem of black subject of neural neighborhood and extra make the teaching outcomes interpretable in neural neighborhood, we use the idea of knockoffs to assemble the knockoff attribute genes of the distinctive attribute genes. This system not solely make each attribute gene to compete with each other, however moreover make each attribute gene compete with its knockoff attribute gene. This methodology could assist to choose the vital factor genes that affect the decision-making of neural networks.

Outcomes: We use maize carotenoids, tocopherol methyltransferase, raffinose family oligosaccharides and human breast most cancers dataset to do verification and analysis.

Conclusions: The experiment outcomes show that the knockoffs optimizing neural neighborhood methodology has greater detection influence than the alternative current algorithms, and particularly for processing the nonlinear gene expression and phenotype data.

immusol
immusol

Fenretinide

GP8861-25MG 25 mg
EUR 170.4

Fenretinide

HY-15373 10mM/1mL
EUR 151.2

Single cell transcriptomes reveal expression patterns of chemoreceptor genes in olfactory sensory neurons of the Caribbean spiny lobster, Panulirus argus

Background: Crustaceans categorical various programs of receptor genes of their antennules, which house olfactory sensory neurons (OSNs) and non-olfactory chemosensory neurons. Transcriptomics analysis reveal that candidate chemoreceptor proteins embrace variant Ionotropic Receptors (IRs) along with every co-receptor IRs and tuning IRs, Transient Receptor Potential (TRP) channels, Gustatory Receptors, epithelial sodium channels, and class A G-protein coupled receptors (GPCRs). The Caribbean spiny lobster, Panulirus argus, expresses in its antennules nearly 600 IRs, 17 TRP channels, 1 Gustatory Receptor, 7 epithelial sodium channels, 81 GPCRs, 6 G proteins, and dozens of enzymes in signaling pathways.

Nonetheless, the exact combinatorial expression patterns of these proteins in single sensory neurons often are usually not acknowledged for any crustacean, limiting our understanding of how their chemosensory methods encode chemical top quality.

Outcomes: The aim of this analysis was to utilize transcriptomics to elucidate expression patterns of chemoreceptor genes in OSNs of P. argus. We generated and analyzed transcriptomes from 7 single OSNs, a couple of of which have been confirmed to reply a meals odor, along with an additional 7 multicell transcriptomes from preparations containing few (2-4), various (ca. 15), or many (ca. 400) OSNs.

We found that each OSN expressed the an identical 2 co-receptor IRs (IR25a, IR93a) nonetheless not the alternative 2 antennular coIRs (IR8a, IR76b), 9-53 tuning IRs nonetheless only one to some in extreme abundance, the an identical 5 TRP channels plus as a lot as 5 further TRPs, 12-17 GPCRs along with the an identical 5 expressed in every single cell transcriptome, the an identical Three G proteins plus others, many enzymes throughout the signaling pathways, nonetheless no Gustatory Receptors or epithelial sodium channels. The perfect distinction in receptor expression among the many many OSNs was the identification of the tuning IRs.

Conclusions: Our outcomes current an preliminary view of the combinatorial expression patterns of receptor molecules in single OSNs in a single species of decapod crustacean, along with receptors straight involved in olfactory transduction and others likely involved in modulation. Our outcomes moreover counsel variations in receptor expression in OSNs vs. totally different chemosensory neurons.

Camel Genetic Property Conservation by Tourism: A Key Sociocultural Methodology of Camelback Leisure Driving

  • Camels are distinctive elements, which can be comprised inside journey journey companies promoting ecotourism actions. Such recreations contribute to sustainable livelihoods for native communities and educational empowerment within the route of nature and its conservation.
  • At present, some native camel breeds’ survival reduces to this animal-based leisure enterprise and its reliability to hold out and promote custom-made corporations By conducting an on-site questionnaire to prospects collaborating in camelback driving excursions, we assessed the motivational elements affecting participation, satisfaction, and loyalty on this tourism section that can have made it socially differentiated.
  • The sixfold combination of staff effectivity, custom geography, quite a few and humane shut interaction, camel conduct and effectivity, sociotemporal context, and constructive earlier experience consists of the elemental dimensions that designate purchaser satisfaction and return intention likelihood inside this leisure enterprise.
  • Purchaser knowledge is essential for stakeholders to assemble personalised driving experiences and align earnings with environmental sustainability and biodiversity mainstream issues into their regularly operations. In flip, house camel vacationer rides could be managed as a viable path to nature conservation by serving to endangered native breeds to steer clear of their helpful devaluation and potential extinction.

gel casting base for evs3100

EVS3100-BASE ea
EUR 361.2

gel casting base for evs3200

EVS3200-BASE ea
EUR 361.2

gel casting base for evs3300

EVS3300-BASE ea
EUR 361.2

Rucaparib (free base)

A8893-10 10 mg
EUR 240
Description: Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway.

Rucaparib (free base)

A8893-200 200 mg
EUR 1243.2
Description: Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway.

Rucaparib (free base)

A8893-5 5 mg
EUR 164.4
Description: Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway.

Rucaparib (free base)

A8893-5.1 10 mM (in 1mL DMSO)
EUR 170.4
Description: Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway.

Rucaparib (free base)

A8893-50 50 mg
EUR 547.2
Description: Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway.

R406 (free base)

A5880-100 100 mg
EUR 1452
Description: R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins.

R406 (free base)

A5880-25 25 mg
EUR 616.8
Description: R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins.

R406 (free base)

A5880-5 5 mg
EUR 199.2
Description: R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins.

R406 (free base)

A5880-5.1 10 mM (in 1mL DMSO)
EUR 316.8
Description: R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins.

R406 (free base)

A5880-S Evaluation Sample
EUR 97.2
Description: R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins.

AZD4547, Free Base

ADC-P-063 unit Ask for price

AZD8055, Free Base

ADC-P-064 unit Ask for price

Cyclopamine, Free Base

ADC-P-079 unit Ask for price

Ixabepilone, Free Base

ADC-P-104 unit Ask for price

R406(free base)

E1KS1533 2mg
EUR 625.2

Lapatinib, Free base

2138-100
EUR 464.4

Lapatinib, Free base

2138-25
EUR 229.2

Ruxolitinib, Free base

2139-100 Ask for price

Ruxolitinib, Free base

2139-25
EUR 639.6

Ruxolitinib, Free base

2139-5
EUR 248.4

Imatinib, Free base

2141-100
EUR 176.4

Imatinib, Free base

2141-1000
EUR 502.8

Linsitinib, Free base

2294-25
EUR 679.2

Linsitinib, Free base

2294-5
EUR 222

Tipifarnib, Free base

2296-1
EUR 170.4

Tipifarnib, Free base

2296-5
EUR 496.8

Erlotinib, Free Base

2048-100
EUR 189.6

Erlotinib, Free Base

2048-1000
EUR 464.4

Sunitinib, Free base

2097-100
EUR 229.2

Sunitinib, Free base

2097-1000
EUR 601.2

Sunitinib, Free base

2097-25
EUR 138

Vatalanib, Free Base

2026-25
EUR 366

Vatalanib, Free Base

2026-5
EUR 151.2

Ruxolitinib (free base)

10-042 25 mg
EUR 418.2
Description: Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50=322nM). Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro. It is investigated against the spread of the SARS-CoV-2 (COVID-19).

LY2835219 free base

A3575-100 100 mg
EUR 686.4
Description: LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity.

LY2835219 free base

A3575-25 25 mg
EUR 309.6
Description: LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity.

LY2835219 free base

A3575-5 5 mg
EUR 170.4
Description: LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity.

THZ1 (Free base)

9664-25
EUR 1227.6

THZ1 (Free base)

9664-5
EUR 352.8

FIPI (free base)

B2372-25
EUR 757.2

FIPI (free base)

B2372-5
EUR 235.2

Terbinafine (Free base)

B2423-250
EUR 248.4

Terbinafine (Free base)

B2423-50
EUR 144

PLX5622 (free base)

B2965-25 25 mg
EUR 903.6

PLX5622 (free base)

B2965-5 5 mg
EUR 272.4

MCC950 (Free base)

B1031-1
EUR 183.6

MCC950 (Free base)

B1031-5
EUR 548.4

Apatinib (Free base)

B1613-25
EUR 496.8

Apatinib (Free base)

B1613-5
EUR 170.4

Carubicin (Free base)

B1853-1
EUR 183.6

Carubicin (Free base)

B1853-5
EUR 548.4

YM158 (free base)

HY-U00355 1mg
EUR 2770.8

Vatalanib (free base)

HY-10203 5mg
EUR 142.8

Masupirdine (free base)

HY-109118 1mg
EUR 267.6

R406 (free base)

HY-11108 10mM/1mL
EUR 277.2

ITI214 (free base)

HY-12501 100mg
EUR 3531.6

AS2863619 (free base)

HY-126675 5mg
EUR 1410

AZD3839 (free base)

HY-13438 50mg
EUR 1216.8

Ripasudil free base

HY-15685A 10mg
EUR 489.6

RPR107393 free base

HY-100299 1mg
EUR 577.2

FR167344 free base

HY-100301 1mg
EUR 3164.4

FR183998 free base

HY-100302 1mg
EUR 1352.4

FR194738 free base

HY-100303 1mg
EUR 2388

Xylazine (free base)

Q-1445.0025 25.0g
EUR 385.2
Description: Sum Formula: C12H16N2S; CAS# [7361-61-7]

TMB free base

TB0954 1g
EUR 85.06

Afatinib

A170-100MG 100mg
EUR 122.4

Afatinib

HY-10261 200mg
EUR 374.4

SGI-1776 free base

A4192-10 10 mg
EUR 296.4
Description: SGI-1776 free base, N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival.

SGI-1776 free base

A4192-5 5 mg
EUR 184.8
Description: SGI-1776 free base, N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival.

SGI-1776 free base

A4192-5.1 10 mM (in 1mL DMSO)
EUR 199.2
Description: SGI-1776 free base, N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival.

SGI-1776 free base

A4192-50 50 mg
EUR 630
Description: SGI-1776 free base, N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival.

SGI-1776 free base

A4192-S Evaluation Sample
EUR 97.2
Description: SGI-1776 free base, N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival.

StemRegenin 1, Free base

2642-1
EUR 157.2

StemRegenin 1, Free base

2642-5
EUR 398.4

GSK-J4 (Free base)

2762-1
EUR 144

GSK-J4 (Free base)

2762-5
EUR 314.4

RGB-286638,  free base

2886-25
EUR 907.2

RGB-286638,  free base

2886-5
EUR 274.8

AM-095 free base

A3167-10 10 mg
EUR 254.4
Description: AM095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (LPA1) with IC50 values of 0.73 and 0.98 ?M for mouse or recombinant human LPA1, respectively [1].

AM-095 free base

A3167-100 100 mg
EUR 964.8
Description: AM095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (LPA1) with IC50 values of 0.73 and 0.98 ?M for mouse or recombinant human LPA1, respectively [1].

AM-095 free base

A3167-200 200 mg
EUR 1382.4
Description: AM095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (LPA1) with IC50 values of 0.73 and 0.98 ?M for mouse or recombinant human LPA1, respectively [1].

AM-095 free base

A3167-5 5 mg
EUR 199.2
Description: AM095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (LPA1) with IC50 values of 0.73 and 0.98 ?M for mouse or recombinant human LPA1, respectively [1].

AM-095 free base

A3167-50 50 mg
EUR 686.4
Description: AM095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (LPA1) with IC50 values of 0.73 and 0.98 ?M for mouse or recombinant human LPA1, respectively [1].

L-Arginine free base

AB0205 100g
EUR 75.78

Staurosporine, >99% Free Base

BC090-001 1mg
EUR 295.2

Staurosporine, >99% Free Base

BC090-005 5mg
EUR 408

Vandetanib, >99% Free Base

BC098-025 25mg
EUR 278.4

Vandetanib, >99% Free Base

BC098-050 50mg
EUR 343.2

Vandetanib, >99% Free Base

BC098-100 100mg
EUR 375.6

Vandetanib, >100% Free Base

BC098-500 500mg
EUR 789.6

SB-334867 free base

B3423-100 100 mg
EUR 718.8
Description: SB-334867 free base is a selective antagonist of orexin-1 receptor [1].Orexin-A and orexin-B are two peptides isolated from rat hypothalamus. They are involved in some physiological functions such as the control of feeding, energy metabolism and regulation of the sleep-wake cycle.

SB-334867 free base

B3423-25 25 mg
EUR 348
Description: SB-334867 free base is a selective antagonist of orexin-1 receptor [1].Orexin-A and orexin-B are two peptides isolated from rat hypothalamus. They are involved in some physiological functions such as the control of feeding, energy metabolism and regulation of the sleep-wake cycle.

SB-334867 free base

B3423-5 5 mg
EUR 153.6
Description: SB-334867 free base is a selective antagonist of orexin-1 receptor [1].Orexin-A and orexin-B are two peptides isolated from rat hypothalamus. They are involved in some physiological functions such as the control of feeding, energy metabolism and regulation of the sleep-wake cycle.

SB-334867 free base

B3423-5.1 10 mM (in 1mL DMSO)
EUR 157.2
Description: SB-334867 free base is a selective antagonist of orexin-1 receptor [1].Orexin-A and orexin-B are two peptides isolated from rat hypothalamus. They are involved in some physiological functions such as the control of feeding, energy metabolism and regulation of the sleep-wake cycle.

BMS-345541(free base)

B4655-10 10 mg
EUR 282
Description: BMS-345541(free base) is a selective inhibitor of IKK-1 and IKK-2 with IC50 value of 4?M and 0.3?M, respectively [1].IKK is also known as nuclear factor kappa-B kinase subunit inhibitor and involves in cytokine-activated intracellular signaling pathways.

BMS-345541(free base)

B4655-5 5 mg
EUR 205.2
Description: BMS-345541(free base) is a selective inhibitor of IKK-1 and IKK-2 with IC50 value of 4?M and 0.3?M, respectively [1].IKK is also known as nuclear factor kappa-B kinase subunit inhibitor and involves in cytokine-activated intracellular signaling pathways.

BMS-345541(free base)

B4655-50 50 mg
EUR 714
Description: BMS-345541(free base) is a selective inhibitor of IKK-1 and IKK-2 with IC50 value of 4?M and 0.3?M, respectively [1].IKK is also known as nuclear factor kappa-B kinase subunit inhibitor and involves in cytokine-activated intracellular signaling pathways.

GSK J4 free base

B5959-10 10 mg
EUR 447.6
Description: GSK J4 free base

GSK J4 free base

B5959-50 50 mg
EUR 1437.6
Description: GSK J4 free base

BMS-345541 (Free base)

B1907-1
EUR 170.4

BMS-345541 (Free base)

B1907-5
EUR 496.8

UNC-926, free base

B2158-25
EUR 757.2

UNC-926, free base

B2158-5
EUR 235.2

CP-319340(free base)

HY-U00270 5mg
EUR 1052.4

AV-412 (free base)

HY-10346A 5mg
EUR 207.6

SB-334867 (free base)

HY-10895A 10mg
EUR 258

SNT-207858 (free base)

HY-11030A 10mg
EUR 1093.2

APX-115 (free base)

HY-120801A 5mg
EUR 267.6

LY-2584702 (free base)

HY-12493 5mg
EUR 198

Genz-123346 (free base)

HY-12744 10mM/1mL
EUR 226.8

YHO-13351 (free base)

HY-12758A 10mM/1mL
EUR 211.2

JTV-519 (free base)

HY-15293A 5mg
EUR 680.4

RGB-286638 (free base)

HY-15504A 100mg
EUR 3364.8

DOV-216,303 (Free Base)

HY-18332C 10mM/1mL
EUR 590.4

FK-448 Free base

HY-100193 10mg
EUR 2264.4

KW-8232 free base

HY-100304 10mg
EUR 6021.6

YM-53601 free base

HY-100313 1mg
EUR 1870.8

Z-NHNH2 (free base)

Q-1150.0025 25.0g
EUR 151.2
Description: Sum Formula: C8H10N2O2; CAS# [5331-43-1]

Z-NHNH2 (free base)

Q-1150.0100 100.0g
EUR 385.2
Description: Sum Formula: C8H10N2O2; CAS# [5331-43-1]

Afatinib dimaleate

A3145-10 10 mg
EUR 265.2
Description: Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

Afatinib dimaleate

A3145-5 5 mg
EUR 176.4
Description: Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

Afatinib dimaleate

A3145-5.1 10 mM (in 1mL DMSO)
EUR 142.8
Description: Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

Afatinib dimaleate

A3145-50 50 mg
EUR 614.4
Description: Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

Afatinib (BIBW2992)

A8247-10 10 mg
EUR 265.2
Description: Afatinib (BIBW2992), an irreversible inhibitor of the ErbB family of tyrosine kinases, downregulates ErbB signalling by binding to the kinase domains of epidermal growth factor receptor (EGFR)/ human epidermal growth factor receptor 2 (HER2) with IC50 of 0.5 nM and 14nM, respectively.

Afatinib (BIBW2992)

A8247-5 5 mg
EUR 176.4
Description: Afatinib (BIBW2992), an irreversible inhibitor of the ErbB family of tyrosine kinases, downregulates ErbB signalling by binding to the kinase domains of epidermal growth factor receptor (EGFR)/ human epidermal growth factor receptor 2 (HER2) with IC50 of 0.5 nM and 14nM, respectively.

Afatinib (BIBW2992)

A8247-5.1 10 mM (in 1mL DMSO)
EUR 292.8
Description: Afatinib (BIBW2992), an irreversible inhibitor of the ErbB family of tyrosine kinases, downregulates ErbB signalling by binding to the kinase domains of epidermal growth factor receptor (EGFR)/ human epidermal growth factor receptor 2 (HER2) with IC50 of 0.5 nM and 14nM, respectively.

Afatinib (BIBW2992)

A8247-50 50 mg
EUR 614.4
Description: Afatinib (BIBW2992), an irreversible inhibitor of the ErbB family of tyrosine kinases, downregulates ErbB signalling by binding to the kinase domains of epidermal growth factor receptor (EGFR)/ human epidermal growth factor receptor 2 (HER2) with IC50 of 0.5 nM and 14nM, respectively.

Afatinib (BIBW2992)

A8247-S Evaluation Sample
EUR 97.2
Description: Afatinib (BIBW2992), an irreversible inhibitor of the ErbB family of tyrosine kinases, downregulates ErbB signalling by binding to the kinase domains of epidermal growth factor receptor (EGFR)/ human epidermal growth factor receptor 2 (HER2) with IC50 of 0.5 nM and 14nM, respectively.

Afatinib (dimaleate)

HY-10261A 200mg
EUR 374.4

Human Free PSA (f-PSA) ELISA Kit

PRB-5049-FREE 96 assays
EUR 686.4

H-Tyr-OEt (free base)

E-2900.0025 25.0g
EUR 166.8
Description: Sum Formula: C11H15NO3; CAS# [949-67-7]

H-Tyr-OEt (free base)

E-2900.0100 100.0g
EUR 428.4
Description: Sum Formula: C11H15NO3; CAS# [949-67-7]

Biotin ethylenediamine (free base form)

90071 25MG
EUR 158.4
Description: Minimum order quantity: 1 unit of 25MG

biotin cadaverine, free base form

90079 50MG
EUR 258
Description: Minimum order quantity: 1 unit of 50MG

BAY 43-9006, Free base

2142-100
EUR 502.8

BAY 43-9006, Free base

2142-25
EUR 202.8

BAY 58-2667 (Free base)

2452-1
EUR 424.8

BAY 58-2667 (Free base)

2452-5
EUR 1358.4

EZSolution? StemRegenin 1, Free base

2643-1
EUR 170.4

SB 202190, >99% Free Base

BC086-025 25mg
EUR 246

SB 202190, >99% Free Base

BC086-050 50mg
EUR 295.2

SB 203580, >99% Free Base

BC087-025 25mg
EUR 262.8

SB 203580, >99% Free Base

BC087-050 50mg
EUR 343.2

Glyoxalase I inhibitor (free base)

HY-15167A 50mg
EUR 3036

Bay 65-1942 (free base)

HY-50949 10mg
EUR 1282.8

Gastrofensin AN 5 free base

HY-100296 5mg
EUR 2544

H-Arg(Mtr)-OtBu (free base)

E-3075.0001 1.0g
EUR 370.8
Description: Sum Formula: C20H34N4O5S; CAS# [115608-61-2]

H-Arg(Mtr)-OtBu (free base)

E-3075.0005 5.0g
EUR 1371.6
Description: Sum Formula: C20H34N4O5S; CAS# [115608-61-2]

H-Arg(Pmc)-OtBu (free base)

E-3085.0001 1.0g
EUR 501.6
Description: Sum Formula: C24H40N4O5S; CAS# [169543-81-1]

H-Arg(Pmc)-OtBu (free base)

E-3085.0005 5.0g
EUR 1864.8
Description: Sum Formula: C24H40N4O5S; CAS# [169543-81-1]

biotin-x cadaverine, free base form

90080 20MG
EUR 258
Description: Minimum order quantity: 1 unit of 20MG

Cyclosporin A-Derivative 1 (Free base)

HY-P1355A 1mg
EUR 267.6

PNU-282987 (S enantiomer free base)

HY-12560D 5mg
EUR 1216.8

Human Free PSA (f-PSA) ELISA Kit

PRB-5049-FREE-5 5 x 96 assays
EUR 2739.6

CHIR 99021, GSK-3 Inhibitor , Free Base

BC212-002 2 mg
EUR 213.6

CHIR 99021, GSK-3 Inhibitor , Free Base

BC212-005 5 mg
EUR 318

CHIR 99021, GSK-3 Inhibitor , Free Base

BC212-010 10 mg
EUR 378

CHIR 99021, GSK-3 Inhibitor , Free Base

BC212-025 25 mg
EUR 472.8

CHIR 99021, GSK-3 Inhibitor , Free Base

BC212-100 100 mg
EUR 1064.4

H-Ala-Ala-Phe-AMC (free base)

I-1415.0050 50.0mg
EUR 181.2
Description: Sum Formula: C25H28N4O5; CAS# [62037-41-6]

H-Ala-Ala-Phe-AMC (free base)

I-1415.0250 250.0mg
EUR 618
Description: Sum Formula: C25H28N4O5; CAS# [62037-41-6]

(D-Ser(tBu)6,Azagly10)-LHRH (free base)

H-7296.0005 5.0mg
EUR 219.6
Description: Sum Formula: C59H84N18O14; CAS# [65807-02-5]

(D-Ser(tBu)6,Azagly10)-LHRH (free base)

H-7296.0025 25.0mg
EUR 769.2
Description: Sum Formula: C59H84N18O14; CAS# [65807-02-5]

casting base

EHS3100-CAST ea
EUR 128.4

casting base

EHS3200-CAST ea
EUR 148.8

casting base

EHS3300-CAST ea
EUR 148.8

Tris-base

20-abx082498
  • EUR 393.60
  • EUR 243.60
  • EUR 493.20
  • 1 kg
  • 500 g
  • 5 kg

Tetracycline base

GA9779-100G 100 g
EUR 180

Tetracycline base

GA9779-10G 10 g
EUR 55.2

Tetracycline base

GA9779-25G 25 g
EUR 74.4

Rimonabant base

GX9120-10MG 10 mg
EUR 103.2

Rimonabant base

GX9120-25MG 25 mg
EUR 156

ProteoIQ Base

PS2 1
EUR 5114.4

Vincamine base

Q-1435.0005 5.0g
EUR 270
Description: Sum Formula: C21H26N2O3; CAS# [1617-90-9]

Vincamine base

Q-1435.0025 25.0g
EUR 963.6
Description: Sum Formula: C21H26N2O3; CAS# [1617-90-9]

Positioning Base

S44I041002 EACH
EUR 1409.04

Channel Base

C653 EACH
EUR 22.46

CETRIMIDE AGAR BASE

C03-107-10kg 10 kg
EUR 1474.8

CETRIMIDE AGAR BASE

C03-107-2Kg 2 Kg
EUR 367.2

CETRIMIDE AGAR BASE

C03-107-500g 500 g
EUR 144

MYCOPLASMA BROTH BASE

M13-136-10kg 10 kg
EUR 2108.4

MYCOPLASMA BROTH BASE

M13-136-2kg 2kg
EUR 505.2

MYCOPLASMA BROTH BASE

M13-136-500g 500 g
EUR 181.2

Related articles

immusol

Affiliation evaluation of the surfactant protein-C gene

The Full Chloroplast Genome of Arabidopsis thaliana Remoted in Korea (Brassicaceae): An Investigation of Intraspecific Variations of the Chloroplast Genome of Korean A. thaliana Arabidopsis thaliana (L.) Heynh. is a mannequin organism of plant molecular biology. Greater than 1,700 full genome sequences have been sequenced, nonetheless no Korean isolate genomes have been sequenced up to […]

Learn More
immusol

genome-scale fashions to optimize nutrient present for sustained algal progress

Using genome-scale fashions to optimize nutrient current for sustained algal progress and lipid productiveness Nutrient availability is essential for progress of algae and completely totally different microbes used for producing worthwhile biochemical merchandise. Figuring out the optimum ranges of nutrient presents to cultures can eradicate feeding of further dietary nutritional vitamins, lowering manufacturing prices and […]

Learn More
immusol

Novel Gene Rearrangement and the Full Mitochondrial Genome of Cynoglossusmonopus

Novel Gene Rearrangement and the Full Mitochondrial Genome of Cynoglossusmonopus: Insights into the Envolution of the Household Cynoglossidae (Pleuronectiformes) Cynoglossusmonopus, a small benthic fish, belongs to the Cynoglossidae, Pleuronectiformes. It was not often studied because of its low abundance and cryptical life-style. With the intention to know the mitochondrial genome and the phylogeny in Cynoglossidae, […]

Learn More

Leave a Reply

Your email address will not be published. Required fields are marked *