Single cell transcriptomes reveal expression patterns of chemoreceptor genes

immusol

Melting dsDNA Donor Molecules Vastly Improves Precision Genome Enhancing in Caenorhabditiselegans

CRISPR genome modifying has revolutionized genetics in quite a few organisms. Contained in the nematode Caenorhabditiselegans one injection into every of the 2 gonad arms of an grownup hermaphrodite exposes tons of of meiotic germ cells to modifying mixtures, allowing the restoration of quite a lot of indels or small precision edits from every successfully injected animal. Sadly, significantly for extended insertions, modifying efficiencies can differ broadly, necessitating quite a lot of injections, and usually requiring co-selection methods.

Correct proper right here we present that melting double stranded DNA (dsDNA) donor molecules earlier to injection will enhance the frequency of tangible homology-directed restore (HDR) by quite a lot of fold for longer edits.

We describe troubleshooting methods that allow persistently excessive modifying efficiencies ensuing, as an illustration, in as lots as 100 unbiased GFP knock-ins from a single injected animal. These efficiencies make C. elegans by far the most effective metazoan to genome edit, eradicating limitations to the use and adoption of this facile system as a mannequin for understanding animal biology.

An embedded gene choice methodology utilizing knockoffs optimizing neural community

 Background: Gene alternative refers to find a small subset of discriminant genes from the gene expression profiles. The way in which to decide on genes that affect specific phenotypic traits efficiently is a crucial evaluation work throughout the topic of biology. The neural neighborhood has greater changing into functionality when dealing with nonlinear data, and it’ll most likely seize choices robotically and flexibly. On this work, we recommend an embedded gene alternative methodology using neural neighborhood.

The important genes could also be obtained by calculating the burden coefficient after the teaching is completed. In an effort to treatment the problem of black subject of neural neighborhood and extra make the teaching outcomes interpretable in neural neighborhood, we use the idea of knockoffs to assemble the knockoff attribute genes of the distinctive attribute genes. This system not solely make each attribute gene to compete with each other, however moreover make each attribute gene compete with its knockoff attribute gene. This methodology could assist to choose the vital factor genes that affect the decision-making of neural networks.

Outcomes: We use maize carotenoids, tocopherol methyltransferase, raffinose family oligosaccharides and human breast most cancers dataset to do verification and analysis.

Conclusions: The experiment outcomes show that the knockoffs optimizing neural neighborhood methodology has greater detection influence than the alternative current algorithms, and particularly for processing the nonlinear gene expression and phenotype data.

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immusol

Fenretinide

GP8861-10MG 10 mg
EUR 112.8

Fenretinide

GP8861-25MG 25 mg
EUR 170.4

Fenretinide

GP8861-10 10
EUR 63.3

Fenretinide

GP8861-25 25
EUR 110.7

Fen1/ Rat Fen1 ELISA Kit

ELI-27513r 96 Tests
EUR 1063.2

1000 ug/mL Fenthion in Acetone

S-2010-AC 1ML
EUR 168

FEN1

enz-468 5µg
EUR 60
Description: Recombinant Human Flap Structure-Specific Endonuclease 1

1000 ug/mL Fenobucarb in Acetone

S-4610-AC 1ML
EUR 94.8

1000 ug/mL Fenpyroximate in Acetone

S-5804 1ML
EUR 230.4

FEN1 siRNA

20-abx916746
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

FEN1 siRNA

20-abx916747
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

1000 ug/mL Fenamidone in HPLC Acetonitrile

LCS-4966 1ML
EUR 346.8

1000 ug/mL Fenazaquin in HPLC Acetonitrile

LCS-6019 1ML
EUR 354

1000 ug/mL of Fenitrothion in Acetone 1mL Ampule

S-2001 1ML
EUR 60

FEN1 protein

30R-1442 100 ug
EUR 476.4
Description: Purified recombinant Human FEN1 protein

FEN1 Rabbit pAb

A1175-100ul 100 ul
EUR 369.6

FEN1 Rabbit pAb

A1175-200ul 200 ul
EUR 550.8

FEN1 Rabbit pAb

A1175-20ul 20 ul
EUR 219.6

FEN1 Rabbit pAb

A1175-50ul 50 ul
EUR 267.6

FEN1 Rabbit pAb

A0129-100ul 100 ul
EUR 369.6

FEN1 Rabbit pAb

A0129-200ul 200 ul
EUR 550.8

FEN1 Rabbit pAb

A0129-20ul 20 ul Ask for price

FEN1 Rabbit pAb

A0129-50ul 50 ul Ask for price

FEN1 Rabbit mAb

A8999 20 μL
EUR 18

FEN1 Rabbit pAb

E2381904 100ul
EUR 225
Description: Available in various conjugation types.

FEN1 Rabbit pAb

E2501175 100ul
EUR 225
Description: Available in various conjugation types.

FEN1 Rabbit mAb

E2R26747 100ul
EUR 255
Description: Available in various conjugation types.

1000 ug/mL (E)-Fenpyroximate in Acetonitrile

S-6179 1ML
EUR 121.2

FEN1 antibody

10R-1738 100 ug
EUR 614.4
Description: Mouse monoclonal FEN1 antibody

FEN1 antibody

70R-17281 50 ul
EUR 522
Description: Rabbit polyclonal FEN1 antibody

FEN1 antibody

70R-1605 100 ug
EUR 452.4
Description: Rabbit polyclonal FEN1 antibody raised against the C terminal of FEN1

FEN1 antibody

70R-31706 100 ug
EUR 392.4
Description: Rabbit polyclonal FEN1 antibody

FEN1 antibody

70R-49736 100 ul
EUR 292.8
Description: Purified Polyclonal FEN1 antibody

FEN1 Antibody

33763-100ul 100ul
EUR 302.4

FEN1 Antibody

33763-50ul 50ul
EUR 224.4

FEN1 Antibody

32204-100ul 100ul
EUR 302.4

FEN1 Antibody

ABD13091 100 ug
EUR 525.6

FEN1 Antibody

ABD3172 100 ug
EUR 525.6

FEN1 Antibody

ABD6309 100 ug
EUR 525.6

FEN1 Antibody

DF3172 200ul
EUR 420

FEN1 Antibody

CSB-PA926648- each
EUR 402
Description: A polyclonal antibody against FEN1. Recognizes FEN1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500

FEN1 Antibody

CSB-PA926648-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against FEN1. Recognizes FEN1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500

FEN1 Antibody

CSB-PA008585KA01HU- each
EUR 402
Description: A polyclonal antibody against FEN1. Recognizes FEN1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

FEN1 Antibody

CSB-PA008585KA01HU-100ul 100ul
EUR 466.8
Description: A polyclonal antibody against FEN1. Recognizes FEN1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

FEN1 Antibody

1-CSB-PA008585GA01HU
  • EUR 716.40
  • EUR 399.60
  • 150ul
  • 50ul
Description: A polyclonal antibody against FEN1. Recognizes FEN1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

FEN1 Antibody

1-CSB-PA002510
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FEN1. Recognizes FEN1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/20000

FEN-1 Antibody

RQ5695 100 ug
EUR 356.15
Description: Flap endonuclease 1 is an enzyme that in humans is encoded by the FEN1 gene. It is mapped to 11q12.2. The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.

FEN1 Antibody

DF6309 100ul
EUR 280
Description: Human,Mouse,Rat

FEN1 Antibody

E11-10585C 100μg
EUR 225
Description: Available in various conjugation types.

FEN1 Antibody

E033763 100μg/100μl
EUR 255
Description: Available in various conjugation types.

FEN1 Antibody

E309179 200ul
EUR 275
Description: Available in various conjugation types.

FEN1 Antibody

E38PA1417 100ul
EUR 225
Description: Available in various conjugation types.

FEN1 Antibody

E19-3172 100μg/100μl
EUR 225
Description: Available in various conjugation types.

FEN1 Antibody

E19-6309 100μg/100μl
EUR 225
Description: Available in various conjugation types.

FEN1 Antibody

E91175 100ul
EUR 255
Description: Available in various conjugation types.

FEN1 Antibody

DF6309-100ul 100ul
EUR 280

FEN1 Antibody

DF6309-200ul 200ul
EUR 350

1000 ug/mL (E)-Fenpyroximate in HPLC Acetonitrile

LCS-6179 1ML
EUR 354

1000 ug/mL Fenpyroximate in HPLC Acetonitrile

LCS-6387 1ML
EUR 194.4

1000 ug/mL Fenthion sulfoxide in Acetonitrile

S-4316-ACN 1ML
EUR 111.6

FEN1 ELISA KIT|Human

EF009610 96 Tests
EUR 826.8

anti- FEN1 antibody

FNab03075 100µg
EUR 606.3
Description: Antibody raised against FEN1

Fen1 ORF Vector (Rat) (pORF)

ORF067064 1.0 ug DNA
EUR 607.2

1000 ug/mL Fenthion-sulfone in HPLC Acetonitrile

LCS-6063 1ML
EUR 294

Rat FEN1 shRNA Plasmid

20-abx986959
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

FEN1 (Center) Rabbit pAb

E2614818 100ul
EUR 225
Description: Available in various conjugation types.

1000 ug/mL Fensulfothion-oxon in HPLC Acetonitrile

LCS-6209 1ML
EUR 644.4

1000 ug/mL Fenhexamid in Acetonitrile Volume: 1mL Ampule

S-4962-ACN 1ML
EUR 116.4

1000 ug/mL Fenamidone in Acetonitrile Volume: 1mL Ampule

S-4966-ACN 1ML
EUR 121.2

FEN1 cloning plasmid

CSB-CL008585HU-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the FEN1 gene.

FEN1 ORF Vector (Human) (pORF)

ORF004018 1.0 ug DNA
EUR 114

Fen1 ORF Vector (Mouse) (pORF)

ORF044773 1.0 ug DNA
EUR 607.2

Fen1 3'UTR GFP Stable Cell Line

TU254569 1.0 ml Ask for price

Fen1 3'UTR GFP Stable Cell Line

TU156502 1.0 ml Ask for price

FEN1 3'UTR GFP Stable Cell Line

TU057883 1.0 ml
EUR 1672.8

Rad2 / FEN1 (pS187) Antibody

abx215327-100ug 100 ug
EUR 526.8

Human FEN1 shRNA Plasmid

20-abx951559
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

FEN1 Blocking Peptide

20-abx062611
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

FEN1 Blocking Peptide

33R-7232 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of FEN1 antibody, catalog no. 70R-1605

FEN1 Blocking Peptide

DF6309-BP 1mg
EUR 234

FEN1 Blocking Peptide

DF3172-BP 1mg
EUR 234

FEN1P1 ORF Vector (Human) (pORF)

ORF019564 1.0 ug DNA Ask for price

FEN-1 Polyclonal Antibody

40922-100ul 100ul
EUR 302.4

FEN-1 Polyclonal Antibody

40922-50ul 50ul
EUR 224.4

FEN1 Conjugated Antibody

C32204 100ul
EUR 476.4

FEN-1 Polyclonal Antibody

ABP51337-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of FEN-1 from Human, Mouse, Rat. This FEN-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human FEN-1 at AA range: 60-140

FEN-1 Polyclonal Antibody

ABP51337-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of FEN-1 from Human, Mouse, Rat. This FEN-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human FEN-1 at AA range: 60-140

FEN-1 Polyclonal Antibody

ABP51337-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of FEN-1 from Human, Mouse, Rat. This FEN-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human FEN-1 at AA range: 60-140

FEN-1 Polyclonal Antibody

ES2336-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against FEN-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

FEN-1 Polyclonal Antibody

ES2336-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against FEN-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

FEN1 ELISA Kit (Human) (OKEH08213)

OKEH08213 96 Wells
EUR 1075.2
Description: Description of target: The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Competitive ELISA;Sensitivity: 0.136ng/mL

Fen1 ELISA Kit (Mouse) (OKEH08214)

OKEH08214 96 Wells
EUR 1075.2
Description: Description of target: ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.27ng/mL

FEN1 Protein Vector (Rat) (pPM-C-HA)

PV268256 500 ng
EUR 723.6

Human FEN1 Protein Lysate 20ug

IHUFEN1PLLY20UG each
EUR 213
Description: Human FEN1 Protein Lysate 20ug

FEN-1 Polyclonal Antibody

E040922 100μg/100μl
EUR 255
Description: Available in various conjugation types.

FEN-1 Polyclonal Antibody

E20-71689 100ug
EUR 225
Description: Available in various conjugation types.

1000 ug/mL Fenbutatin-oxide in LCMS Grade AcetoneVolume: 1mL Ampule

LCS-1999-AC 1ML
EUR 217.2

1000 ug/mL Fensulfothion-oxon-sulfone in HPLC Acetonitrile

LCS-6210 1ML
EUR 368.4

FEN1 Recombinant Protein (Rat)

RP201188 100 ug Ask for price

FEN1 Protein Vector (Rat) (pPB-C-His)

PV268254 500 ng
EUR 723.6

FEN1 Protein Vector (Rat) (pPB-N-His)

PV268255 500 ng
EUR 723.6

FEN1 Protein Vector (Rat) (pPM-C-His)

PV268257 500 ng
EUR 723.6

FEN1 Protein Vector (Human) (pPM-C-HA)

PV016071 500 ng
EUR 394.8

FEN1 Protein Vector (Mouse) (pPM-C-HA)

PV179092 500 ng
EUR 723.6

FEN1 (A119) polyclonal antibody

E43S1989 100ul
EUR 225
Description: Available in various conjugation types.

Rad2/FEN1 (Phospho- Ser187) Antibody

ABF8505 100 ug
EUR 525.6

FEN1 Protein Vector (Human) (pPB-C-His)

PV016069 500 ng
EUR 394.8

FEN1 Protein Vector (Human) (pPB-N-His)

PV016070 500 ng
EUR 394.8

FEN1 Protein Vector (Human) (pPM-C-His)

PV016072 500 ng
EUR 394.8

FEN1 Protein Vector (Mouse) (pPB-C-His)

PV179090 500 ng
EUR 723.6

FEN1 Protein Vector (Mouse) (pPB-N-His)

PV179091 500 ng
EUR 723.6

FEN1 Protein Vector (Mouse) (pPM-C-His)

PV179093 500 ng
EUR 723.6

FEN1 Recombinant Protein (Human)

RP012052 100 ug Ask for price

FEN1 Recombinant Protein (Mouse)

RP134315 100 ug Ask for price

FEN1 3'UTR Luciferase Stable Cell Line

TU007883 1.0 ml
EUR 1672.8

Fen1 3'UTR Luciferase Stable Cell Line

TU106502 1.0 ml Ask for price

Fen1 3'UTR Luciferase Stable Cell Line

TU204569 1.0 ml Ask for price

Fen1 sgRNA CRISPR Lentivector set (Rat)

K7115801 3 x 1.0 ug
EUR 406.8

FEN1 Antibody / Flap endonuclease 1

RQ6987 100 ug
EUR 356.15
Description: Flap endonuclease 1 is an enzyme that in humans is encoded by the FEN1 gene. It is mapped to 11q12.2. The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.

FEN1 Antibody / Flap endonuclease 1

RQ6988 100 ug
EUR 356.15
Description: Flap endonuclease 1 is an enzyme that in humans is encoded by the FEN1 gene. It is mapped to 11q12.2. The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.

Rad2/FEN1 (Phospho-Ser187) Antibody

12777-100ul 100ul
EUR 302.4

Rad2/FEN1 (Phospho-Ser187) Antibody

12777-50ul 50ul
EUR 224.4

Human Flap endonuclease 1, FEN1 ELISA KIT

ELI-09496h 96 Tests
EUR 988.8

Mouse Flap endonuclease 1, Fen1 ELISA KIT

ELI-27512m 96 Tests
EUR 1038

Human FEN1/ Flap endonuclease 1 ELISA Kit

E2908Hu 1 Kit
EUR 726

Phospho-Rad2/FEN1 (Ser187) Antibody

AF8505 100ul
EUR 350
Description: Human,Mouse,Rat

Phospho-Rad2/FEN1 (Ser187) Antibody

AF8505-100ul 100ul
EUR 350

Phospho-Rad2/FEN1 (Ser187) Antibody

AF8505-200ul 200ul
EUR 450

Human Flap endonuclease 1 (FEN1) ELISA Kit

RK11007 96T
EUR 280

Bovine Flap endonuclease 1, FEN1 ELISA KIT

ELI-12893b 96 Tests
EUR 1113.6

FEN1 sgRNA CRISPR Lentivector set (Human)

K0774101 3 x 1.0 ug
EUR 406.8

Fen1 sgRNA CRISPR Lentivector set (Mouse)

K3646401 3 x 1.0 ug
EUR 406.8

Recombinant Human FE1/FEN1 Protein, His Tag

E40KMH1081 20ug
EUR 495

Fen1 sgRNA CRISPR Lentivector (Rat) (Target 1)

K7115802 1.0 ug DNA
EUR 184.8

Fen1 sgRNA CRISPR Lentivector (Rat) (Target 2)

K7115803 1.0 ug DNA
EUR 184.8

Fen1 sgRNA CRISPR Lentivector (Rat) (Target 3)

K7115804 1.0 ug DNA
EUR 184.8

Chicken Flap endonuclease 1, FEN1 ELISA KIT

ELI-48473c 96 Tests
EUR 1113.6

Fen1 ELISA Kit| Rat Flap endonuclease 1 ELISA Kit

EF018699 96 Tests
EUR 826.8

FEN-1 Polyclonal Conjugated Antibody

C40922 100ul
EUR 476.4

Rabbit Anti Human Fen1 Polyclonal Antibody

CPBT-67395RH 0.1 mg
EUR 1132.8

FEN1 recombinant monoclonal antibody

A5805 100ul X 3
EUR 714
Description: A recombinant monoclonal antibody from rabbit against human FEN1 for WB, IHC, IF,ELISA

Fen1 ELISA Kit| Mouse Flap endonuclease 1 ELISA Kit

EF014942 96 Tests
EUR 826.8

FEN1 sgRNA CRISPR Lentivector (Human) (Target 1)

K0774102 1.0 ug DNA
EUR 184.8

FEN1 sgRNA CRISPR Lentivector (Human) (Target 2)

K0774103 1.0 ug DNA
EUR 184.8

FEN1 sgRNA CRISPR Lentivector (Human) (Target 3)

K0774104 1.0 ug DNA
EUR 184.8

Fen1 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K3646402 1.0 ug DNA
EUR 184.8

Fen1 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K3646403 1.0 ug DNA
EUR 184.8

Fen1 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K3646404 1.0 ug DNA
EUR 184.8

Recombinant Human Flap Endonuclease 1/FEN-1

C140-10ug 10ug
EUR 187.2
Description: Supplied as a 0.2 μm filtered solution of 50 mM Tris, 50mM NaCl, 1mM DDT, 10% Glycerol, pH 8.0.

Recombinant Human Flap Endonuclease 1/FEN-1

C140-1mg 1mg
EUR 2739.6
Description: Supplied as a 0.2 μm filtered solution of 50 mM Tris, 50mM NaCl, 1mM DDT, 10% Glycerol, pH 8.0.

Recombinant Human Flap Endonuclease 1/FEN-1

C140-500ug 500ug
EUR 1935.6
Description: Supplied as a 0.2 μm filtered solution of 50 mM Tris, 50mM NaCl, 1mM DDT, 10% Glycerol, pH 8.0.

Recombinant Human Flap Endonuclease 1/FEN-1

C140-50ug 50ug
EUR 442.8
Description: Supplied as a 0.2 μm filtered solution of 50 mM Tris, 50mM NaCl, 1mM DDT, 10% Glycerol, pH 8.0.

Phospho-Rad2/FEN1 (Ser187) Blocking Peptide

AF8505-BP 1mg
EUR 234

FEN1 ELISA Kit| Bovine Flap endonuclease 1 ELISA Kit

EF011390 96 Tests
EUR 826.8

Recombinant Pichia pastoris FEN1 Protein (aa 1-373)

VAng-Cr6600-1mgEcoli 1 mg (E. coli)
EUR 5487.6
Description: Pichia pastoris (strain GS115 / ATCC 20864) Flap endonuclease 1 (FEN1), recombinant protein.

Recombinant Pichia pastoris FEN1 Protein (aa 1-373)

VAng-Cr6600-500gEcoli 500 µg (E. coli)
EUR 3870
Description: Pichia pastoris (strain GS115 / ATCC 20864) Flap endonuclease 1 (FEN1), recombinant protein.

Recombinant Pichia pastoris FEN1 Protein (aa 1-373)

VAng-Cr6600-50gEcoli 50 µg (E. coli)
EUR 2650.8
Description: Pichia pastoris (strain GS115 / ATCC 20864) Flap endonuclease 1 (FEN1), recombinant protein.

Recombinant Giardia Lamblia FEN1 Protein (aa 1-361)

VAng-Cr4542-1mgEcoli 1 mg (E. coli)
EUR 5388
Description: Giardia Lamblia Flap endonuclease 1 (FEN1), recombinant protein.

Recombinant Giardia Lamblia FEN1 Protein (aa 1-361)

VAng-Cr4542-500gEcoli 500 µg (E. coli)
EUR 3820.8
Description: Giardia Lamblia Flap endonuclease 1 (FEN1), recombinant protein.

Recombinant Giardia Lamblia FEN1 Protein (aa 1-361)

VAng-Cr4542-50gEcoli 50 µg (E. coli)
EUR 2601.6
Description: Giardia Lamblia Flap endonuclease 1 (FEN1), recombinant protein.

FEN1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV678703 1.0 ug DNA
EUR 818.4

FEN1 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV678707 1.0 ug DNA
EUR 818.4

FEN1 ELISA Kit| chicken Flap endonuclease 1 ELISA Kit

EF012306 96 Tests
EUR 826.8

Recombinant Leishmania Major FEN1 Protein (aa 1-395)

VAng-Wyb7487-1mgEcoli 1 mg (E. coli)
EUR 5652
Description: Leishmania Major Flap endonuclease 1, recombinant protein.

Recombinant Leishmania Major FEN1 Protein (aa 1-395)

VAng-Wyb7487-500gEcoli 500 µg (E. coli)
EUR 4002
Description: Leishmania Major Flap endonuclease 1, recombinant protein.

Recombinant Leishmania Major FEN1 Protein (aa 1-395)

VAng-Wyb7487-50gEcoli 50 µg (E. coli)
EUR 2733.6
Description: Leishmania Major Flap endonuclease 1, recombinant protein.

Recombinant Plasmodium Vivax FEN1 Protein

VAng-Wyb7861-inquire inquire Ask for price
Description: Plasmodium Vivax (strain Salvador I) Flap endonuclease 1, recombinant protein.

Fen1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)

K7115805 3 x 1.0 ug
EUR 451.2

Recombinant Trypanosoma Cruzi FEN1 Protein (aa 1-393)

VAng-Wyb8422-100gBaculovirus 100 µg (Baculovirus)
EUR 5421.6
Description: Trypanosoma Cruzi (strain CL Brener) Flap endonuclease 1 protein, recombinant protein.

Recombinant Trypanosoma Cruzi FEN1 Protein (aa 1-393)

VAng-Wyb8422-500gBaculovirus 500 µg (Baculovirus)
EUR 7022.4
Description: Trypanosoma Cruzi (strain CL Brener) Flap endonuclease 1 protein, recombinant protein.

Recombinant Trypanosoma Cruzi FEN1 Protein (aa 1-393)

VAng-Wyb8422-50gBaculovirus 50 µg (Baculovirus)
EUR 3771.6
Description: Trypanosoma Cruzi (strain CL Brener) Flap endonuclease 1 protein, recombinant protein.

FEN1 Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)

LV678708 1.0 ug DNA
EUR 818.4

Recombinant Trypanosoma Brucei FEN1 Protein (aa 1-393)

VAng-Wyb8072-100gBaculovirus 100 µg (Baculovirus)
EUR 5421.6
Description: Trypanosoma Brucei brucei (strain 927/4 GUTat10.1) Flap endonuclease 1 protein, recombinant protein.

Recombinant Trypanosoma Brucei FEN1 Protein (aa 1-393)

VAng-Wyb8072-500gBaculovirus 500 µg (Baculovirus)
EUR 7022.4
Description: Trypanosoma Brucei brucei (strain 927/4 GUTat10.1) Flap endonuclease 1 protein, recombinant protein.

Recombinant Trypanosoma Brucei FEN1 Protein (aa 1-393)

VAng-Wyb8072-50gBaculovirus 50 µg (Baculovirus)
EUR 3771.6
Description: Trypanosoma Brucei brucei (strain 927/4 GUTat10.1) Flap endonuclease 1 protein, recombinant protein.

Recombinant Aspergillus Niger FEN1 Protein (aa 1-395) [His]

VAng-Wyb3890-1mg 1 mg
EUR 5732.4
Description: Aspergillus Niger (strain CBS 513.88 / FGSC A1513) Flap Structure-Specific Endonuclease 1, recombinant protein.

Fenson

S-4247 1ML
EUR 168

FEN1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K0774105 3 x 1.0 ug
EUR 451.2

Fen1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)

K3646405 3 x 1.0 ug
EUR 451.2

Recombinant Human FEN1 Protein, Untagged, E.coli-1mg

QP11866-1mg 1mg
EUR 4386

Recombinant Human FEN1 Protein, Untagged, E.coli-5ug

QP11866-5ug 5ug
EUR 186

Recombinant Leishmania Infantum FEN1 Protein (aa 1-395)

VAng-Wyb7444-1mgEcoli 1 mg (E. coli)
EUR 5652
Description: Leishmania Infantum Flap endonuclease 1, recombinant protein.

Recombinant Leishmania Infantum FEN1 Protein (aa 1-395)

VAng-Wyb7444-500gEcoli 500 µg (E. coli)
EUR 4002
Description: Leishmania Infantum Flap endonuclease 1, recombinant protein.

Recombinant Leishmania Infantum FEN1 Protein (aa 1-395)

VAng-Wyb7444-50gEcoli 50 µg (E. coli)
EUR 2733.6
Description: Leishmania Infantum Flap endonuclease 1, recombinant protein.

Recombinant Plasmodium Knowlesi FEN1 Protein (aa 1-595)

VAng-Wyb7808-inquire inquire Ask for price
Description: Plasmodium Knowlesi (strain H) Flap endonuclease 1, partial, recombinant protein.

Recombinant Plasmodium Yoelii FEN1 Protein (aa 1-480) (E. coli)

VAng-Wyb7918-inquire inquire Ask for price
Description: Plasmodium Yoelii Flap endonuclease 1 protein, recombinant protein.

Recombinant Trypanosoma Brucei FEN1 Protein (aa 1-393) [His]

VAng-Wyb8074-1mg 1 mg
EUR 5788.8
Description: Trypanosoma Brucei brucei (strain 927/4 GUTat10.1) Flap Structure-Specific Endonuclease 1 protein, recombinant protein.

Recombinant Aspergillus Flavus FEN1 Protein (aa 1-395) [His]

VAng-Wyb3815-1mg 1 mg
EUR 5732.4
Description: Aspergillus Flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167) Flap Structure-Specific Endonuclease 1, recombinant protein.

FEN1P1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV761441 1.0 ug DNA Ask for price

FEN1P1 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

LV761445 1.0 ug DNA Ask for price

Fen1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1)

K7115806 1.0 ug DNA
EUR 200.4

Fen1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)

K7115807 1.0 ug DNA
EUR 200.4

Fen1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3)

K7115808 1.0 ug DNA
EUR 200.4

Recombinant Human FEN1 Protein, Untagged, E.coli-20ug

QP11866-20ug 20ug
EUR 241.2

Recombinant Plasmodium Berghei FEN1 Protein (aa 1-478) (E. coli)

VAng-Wyb7623-inquire inquire Ask for price
Description: Plasmodium Berghei (strain Anka) Flap endonuclease 1 protein, recombinant protein.

Single cell transcriptomes reveal expression patterns of chemoreceptor genes in olfactory sensory neurons of the Caribbean spiny lobster, Panulirus argus

Background: Crustaceans categorical various programs of receptor genes of their antennules, which house olfactory sensory neurons (OSNs) and non-olfactory chemosensory neurons. Transcriptomics analysis reveal that candidate chemoreceptor proteins embrace variant Ionotropic Receptors (IRs) along with every co-receptor IRs and tuning IRs, Transient Receptor Potential (TRP) channels, Gustatory Receptors, epithelial sodium channels, and class A G-protein coupled receptors (GPCRs). The Caribbean spiny lobster, Panulirus argus, expresses in its antennules nearly 600 IRs, 17 TRP channels, 1 Gustatory Receptor, 7 epithelial sodium channels, 81 GPCRs, 6 G proteins, and dozens of enzymes in signaling pathways.

Nonetheless, the exact combinatorial expression patterns of these proteins in single sensory neurons often are usually not acknowledged for any crustacean, limiting our understanding of how their chemosensory methods encode chemical top quality.

Outcomes: The aim of this analysis was to utilize transcriptomics to elucidate expression patterns of chemoreceptor genes in OSNs of P. argus. We generated and analyzed transcriptomes from 7 single OSNs, a couple of of which have been confirmed to reply a meals odor, along with an additional 7 multicell transcriptomes from preparations containing few (2-4), various (ca. 15), or many (ca. 400) OSNs.

We found that each OSN expressed the an identical 2 co-receptor IRs (IR25a, IR93a) nonetheless not the alternative 2 antennular coIRs (IR8a, IR76b), 9-53 tuning IRs nonetheless only one to some in extreme abundance, the an identical 5 TRP channels plus as a lot as 5 further TRPs, 12-17 GPCRs along with the an identical 5 expressed in every single cell transcriptome, the an identical Three G proteins plus others, many enzymes throughout the signaling pathways, nonetheless no Gustatory Receptors or epithelial sodium channels. The perfect distinction in receptor expression among the many many OSNs was the identification of the tuning IRs.

Conclusions: Our outcomes current an preliminary view of the combinatorial expression patterns of receptor molecules in single OSNs in a single species of decapod crustacean, along with receptors straight involved in olfactory transduction and others likely involved in modulation. Our outcomes moreover counsel variations in receptor expression in OSNs vs. totally different chemosensory neurons.

Camel Genetic Property Conservation by Tourism: A Key Sociocultural Methodology of Camelback Leisure Driving

  • Camels are distinctive elements, which can be comprised inside journey journey companies promoting ecotourism actions. Such recreations contribute to sustainable livelihoods for native communities and educational empowerment within the route of nature and its conservation.
  • At present, some native camel breeds’ survival reduces to this animal-based leisure enterprise and its reliability to hold out and promote custom-made corporations By conducting an on-site questionnaire to prospects collaborating in camelback driving excursions, we assessed the motivational elements affecting participation, satisfaction, and loyalty on this tourism section that can have made it socially differentiated.
  • The sixfold combination of staff effectivity, custom geography, quite a few and humane shut interaction, camel conduct and effectivity, sociotemporal context, and constructive earlier experience consists of the elemental dimensions that designate purchaser satisfaction and return intention likelihood inside this leisure enterprise.
  • Purchaser knowledge is essential for stakeholders to assemble personalised driving experiences and align earnings with environmental sustainability and biodiversity mainstream issues into their regularly operations. In flip, house camel vacationer rides could be managed as a viable path to nature conservation by serving to endangered native breeds to steer clear of their helpful devaluation and potential extinction.

Afatinib

HY-10261 200mg
EUR 374.4

Afatinib

GW6150-1 1
EUR 171.5

Afatinib

GW6150-10 10
EUR 368.2

Afatinib

GW6150-5 5
EUR 237.4

Afatinib (BIBW2992)

A8247-10 10 mg
EUR 265.2
Description: Afatinib (BIBW2992), an irreversible inhibitor of the ErbB family of tyrosine kinases, downregulates ErbB signalling by binding to the kinase domains of epidermal growth factor receptor (EGFR)/ human epidermal growth factor receptor 2 (HER2) with IC50 of 0.5 nM and 14nM, respectively.

Afatinib (BIBW2992)

A8247-5 5 mg
EUR 176.4
Description: Afatinib (BIBW2992), an irreversible inhibitor of the ErbB family of tyrosine kinases, downregulates ErbB signalling by binding to the kinase domains of epidermal growth factor receptor (EGFR)/ human epidermal growth factor receptor 2 (HER2) with IC50 of 0.5 nM and 14nM, respectively.

Afatinib (BIBW2992)

A8247-5.1 10 mM (in 1mL DMSO)
EUR 292.8
Description: Afatinib (BIBW2992), an irreversible inhibitor of the ErbB family of tyrosine kinases, downregulates ErbB signalling by binding to the kinase domains of epidermal growth factor receptor (EGFR)/ human epidermal growth factor receptor 2 (HER2) with IC50 of 0.5 nM and 14nM, respectively.

Afatinib (BIBW2992)

A8247-50 50 mg
EUR 614.4
Description: Afatinib (BIBW2992), an irreversible inhibitor of the ErbB family of tyrosine kinases, downregulates ErbB signalling by binding to the kinase domains of epidermal growth factor receptor (EGFR)/ human epidermal growth factor receptor 2 (HER2) with IC50 of 0.5 nM and 14nM, respectively.

Afatinib (BIBW2992)

A8247-S Evaluation Sample
EUR 97.2
Description: Afatinib (BIBW2992), an irreversible inhibitor of the ErbB family of tyrosine kinases, downregulates ErbB signalling by binding to the kinase domains of epidermal growth factor receptor (EGFR)/ human epidermal growth factor receptor 2 (HER2) with IC50 of 0.5 nM and 14nM, respectively.

Afatinib dimaleate

A3145-10 10 mg
EUR 265.2
Description: Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

Afatinib dimaleate

A3145-5 5 mg
EUR 176.4
Description: Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

Afatinib dimaleate

A3145-5.1 10 mM (in 1mL DMSO)
EUR 142.8
Description: Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

Afatinib dimaleate

A3145-50 50 mg
EUR 614.4
Description: Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

Afatinib (dimaleate)

HY-10261A 200mg
EUR 374.4

EGFR/HER2 kinase inhibitor (>99%, M.wt 485.94) (Afatinib/BIBW-2992

SM-101000-5 5 mg
EUR 196.8

EGFR/HER2 kinase inhibitor (>99%, M.wt 485.94) (Afatinib/BIBW-2992

SM-101000-50 50 mg
EUR 781.2

TMB free base

TB0954 1g
EUR 85.06

FIPI (free base)

B2372-25 each
EUR 757.2

FIPI (free base)

B2372-5 each
EUR 235.2

THZ1 (Free base)

9664-25 each
EUR 1227.6

THZ1 (Free base)

9664-5 each
EUR 352.8

R406 (free base)

A5880-100 100 mg
EUR 1452
Description: R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins.

R406 (free base)

A5880-25 25 mg
EUR 616.8
Description: R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins.

R406 (free base)

A5880-5 5 mg
EUR 199.2
Description: R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins.

R406 (free base)

A5880-5.1 10 mM (in 1mL DMSO)
EUR 316.8
Description: R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins.

R406 (free base)

A5880-S Evaluation Sample
EUR 97.2
Description: R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins.

R406(free base)

E1KS1533 2mg
EUR 625.2

R406 (free base)

HY-11108 10mM/1mL
EUR 277.2

YM158 (free base)

HY-U00355 1mg
EUR 2770.8

MCC950 (Free base)

B1031-1 each
EUR 183.6

MCC950 (Free base)

B1031-5 each
EUR 548.4

ITI214 (free base)

HY-12501 100mg
EUR 3531.6

PLX5622 (free base)

B2965-25 25 mg
EUR 903.6

PLX5622 (free base)

B2965-5 5 mg
EUR 272.4

AZD4547, Free Base

ADC-P-063 unit Ask for price

AZD8055, Free Base

ADC-P-064 unit Ask for price

AZD3839 (free base)

HY-13438 50mg
EUR 1216.8

Apatinib (Free base)

B1613-25 each
EUR 496.8

Apatinib (Free base)

B1613-5 each
EUR 170.4

Imatinib, Free base

2141-100 each
EUR 176.4

Imatinib, Free base

2141-1000 each
EUR 502.8

FR167344 free base

HY-100301 1mg
EUR 3164.4

FR183998 free base

HY-100302 1mg
EUR 1352.4

FR194738 free base

HY-100303 1mg
EUR 2388

Xylazine (free base)

Q-1445.0025 25.0g
EUR 385.2
Description: Sum Formula: C12H16N2S; CAS# [7361-61-7]

Lapatinib, Free base

2138-100 each
EUR 464.4

Lapatinib, Free base

2138-25 each
EUR 229.2

Erlotinib, Free Base

2048-100 each
EUR 189.6

Erlotinib, Free Base

2048-1000 each
EUR 464.4

Sunitinib, Free base

2097-100 each
EUR 229.2

Sunitinib, Free base

2097-1000 each
EUR 601.2

Sunitinib, Free base

2097-25 each
EUR 138

Vatalanib, Free Base

2026-25 each
EUR 366

Vatalanib, Free Base

2026-5 each
EUR 151.2

LY2835219 free base

A3575-100 100 mg
EUR 686.4
Description: LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity.

LY2835219 free base

A3575-25 25 mg
EUR 309.6
Description: LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity.

LY2835219 free base

A3575-5 5 mg
EUR 170.4
Description: LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity.

Carubicin (Free base)

B1853-1 each
EUR 183.6

Carubicin (Free base)

B1853-5 each
EUR 548.4

Rucaparib (free base)

A8893-10 10 mg
EUR 240
Description: Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway.

Rucaparib (free base)

A8893-200 200 mg
EUR 1243.2
Description: Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway.

Rucaparib (free base)

A8893-5 5 mg
EUR 164.4
Description: Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway.

Rucaparib (free base)

A8893-5.1 10 mM (in 1mL DMSO)
EUR 170.4
Description: Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway.

Rucaparib (free base)

A8893-50 50 mg
EUR 547.2
Description: Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway.

RPR107393 free base

HY-100299 1mg
EUR 577.2

Vatalanib (free base)

HY-10203 5mg
EUR 142.8

Ripasudil free base

HY-15685A 10mg
EUR 489.6

AS2863619 (free base)

HY-126675 5mg
EUR 1410

Adenosine, Free Base

A2125-100G 100G
EUR 123.2
Description: High Purity

Adenosine, Free Base

A2125-25G 25G
EUR 30.8
Description: High Purity

Linsitinib, Free base

2294-25 each
EUR 679.2

Linsitinib, Free base

2294-5 each
EUR 222

Tipifarnib, Free base

2296-1 each
EUR 170.4

Tipifarnib, Free base

2296-5 each
EUR 496.8

Nintedanib (free base)

GW5215-100 100
EUR 274.7

Nintedanib (free base)

GW5215-25 25
EUR 117.8

Terbinafine (Free base)

B2423-250 each
EUR 248.4

Terbinafine (Free base)

B2423-50 each
EUR 144

Ruxolitinib (free base)

10-042 25 mg
EUR 418.2
Description: Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50=322nM). Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro. It is investigated against the spread of the SARS-CoV-2 (COVID-19).

Cyclopamine, Free Base

27013 10 mg
EUR 130
Description: Cyclopamine inhibits activation of the Hedgehog response pathway by binding to and inhibiting the proto-oncogene Smoothened (SMO). The effects of oncogenic mutations that either activate SMO or inactivate the tumor suppressor Patched (Ptch) can be reversed by cyclopamine treatment. Cyclopamine has also been shown to induce apoptosis in colorectal adenoma cell lines, carcinoma-derived cell lines, and skin basal cell carcinomas and is being investigated as an anti-cancer drug.

Ruxolitinib, Free base

2139-100 each Ask for price

Ruxolitinib, Free base

2139-25 each
EUR 639.6

Ruxolitinib, Free base

2139-5 each
EUR 248.4

Cyclopamine, Free Base

ADC-P-079 unit Ask for price

Ixabepilone, Free Base

ADC-P-104 unit Ask for price

Masupirdine (free base)

HY-109118 1mg
EUR 267.6

Ruxolitinib (free base)

GW2265-100 100
EUR 404.9

Ruxolitinib (free base)

GW2265-25 25
EUR 216.3

Ruxolitinib (free base)

GW2265-5 5
EUR 116.1

GSK J4 free base

B5959-10 10 mg
EUR 447.6
Description: GSK J4 free base

GSK J4 free base

B5959-50 50 mg
EUR 1437.6
Description: GSK J4 free base

DOV-216,303 (Free Base)

HY-18332C 10mM/1mL
EUR 590.4

GSK-J4 (Free base)

2762-1 each
EUR 144

GSK-J4 (Free base)

2762-5 each
EUR 314.4

AM-095 free base

A3167-10 10 mg
EUR 254.4
Description: AM095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (LPA1) with IC50 values of 0.73 and 0.98 ?M for mouse or recombinant human LPA1, respectively [1].

AM-095 free base

A3167-100 100 mg
EUR 964.8
Description: AM095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (LPA1) with IC50 values of 0.73 and 0.98 ?M for mouse or recombinant human LPA1, respectively [1].

AM-095 free base

A3167-200 200 mg
EUR 1382.4
Description: AM095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (LPA1) with IC50 values of 0.73 and 0.98 ?M for mouse or recombinant human LPA1, respectively [1].

AM-095 free base

A3167-5 5 mg
EUR 199.2
Description: AM095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (LPA1) with IC50 values of 0.73 and 0.98 ?M for mouse or recombinant human LPA1, respectively [1].

AM-095 free base

A3167-50 50 mg
EUR 686.4
Description: AM095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (LPA1) with IC50 values of 0.73 and 0.98 ?M for mouse or recombinant human LPA1, respectively [1].

AV-412 (free base)

HY-10346A 5mg
EUR 207.6

FK-448 Free base

HY-100193 10mg
EUR 2264.4

UNC-926, free base

B2158-25 each
EUR 757.2

UNC-926, free base

B2158-5 each
EUR 235.2

KW-8232 free base

HY-100304 10mg
EUR 6021.6

APX-115 (free base)

HY-120801A 5mg
EUR 267.6

JTV-519 (free base)

HY-15293A 5mg
EUR 680.4

Z-NHNH2 (free base)

Q-1150.0025 25.0g
EUR 151.2
Description: Sum Formula: C8H10N2O2; CAS# [5331-43-1]

Z-NHNH2 (free base)

Q-1150.0100 100.0g
EUR 385.2
Description: Sum Formula: C8H10N2O2; CAS# [5331-43-1]

OSI-420 free base

B1495-200 200mg
EUR 2006
Description: EGFR inhibitor

SGI-1776 free base

27651-1 5 mg
EUR 155
Description: SGI-1776 is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival. Through extensive biomedical characterization, SGI-1776 exhibits specificity to the three isoforms of the Pim family, including Pim-1, Pim-2, and Pim-3. Treatment with SGI-1776 induces apoptosis in CLL primary cell line.

SGI-1776 free base

27651-2 10 mg
EUR 235
Description: SGI-1776 is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival. Through extensive biomedical characterization, SGI-1776 exhibits specificity to the three isoforms of the Pim family, including Pim-1, Pim-2, and Pim-3. Treatment with SGI-1776 induces apoptosis in CLL primary cell line.

SGI-1776 free base

27651-3 50 mg
EUR 510
Description: SGI-1776 is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival. Through extensive biomedical characterization, SGI-1776 exhibits specificity to the three isoforms of the Pim family, including Pim-1, Pim-2, and Pim-3. Treatment with SGI-1776 induces apoptosis in CLL primary cell line.

SGI-1776 free base

A4192-10 10 mg
EUR 296.4
Description: SGI-1776 free base, N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival.

SGI-1776 free base

A4192-5 5 mg
EUR 184.8
Description: SGI-1776 free base, N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival.

SGI-1776 free base

A4192-5.1 10 mM (in 1mL DMSO)
EUR 199.2
Description: SGI-1776 free base, N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival.

SGI-1776 free base

A4192-50 50 mg
EUR 630
Description: SGI-1776 free base, N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival.

SGI-1776 free base

A4192-S Evaluation Sample
EUR 97.2
Description: SGI-1776 free base, N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival.

YM-53601 free base

HY-100313 1mg
EUR 1870.8

A-674563 (free base)

GW8742-1 1
EUR 92.4

A-674563 (free base)

GW8742-10 10
EUR 287

A-674563 (free base)

GW8742-5 5
EUR 210.3

Vandetanib, >100% Free Base

BC098-500 500mg
EUR 789.6

SB-334867 free base

B3423-100 100 mg
EUR 718.8
Description: SB-334867 free base is a selective antagonist of orexin-1 receptor [1].Orexin-A and orexin-B are two peptides isolated from rat hypothalamus. They are involved in some physiological functions such as the control of feeding, energy metabolism and regulation of the sleep-wake cycle.

SB-334867 free base

B3423-25 25 mg
EUR 348
Description: SB-334867 free base is a selective antagonist of orexin-1 receptor [1].Orexin-A and orexin-B are two peptides isolated from rat hypothalamus. They are involved in some physiological functions such as the control of feeding, energy metabolism and regulation of the sleep-wake cycle.

SB-334867 free base

B3423-5 5 mg
EUR 153.6
Description: SB-334867 free base is a selective antagonist of orexin-1 receptor [1].Orexin-A and orexin-B are two peptides isolated from rat hypothalamus. They are involved in some physiological functions such as the control of feeding, energy metabolism and regulation of the sleep-wake cycle.

SB-334867 free base

B3423-5.1 10 mM (in 1mL DMSO)
EUR 157.2
Description: SB-334867 free base is a selective antagonist of orexin-1 receptor [1].Orexin-A and orexin-B are two peptides isolated from rat hypothalamus. They are involved in some physiological functions such as the control of feeding, energy metabolism and regulation of the sleep-wake cycle.

CP-319340(free base)

HY-U00270 5mg
EUR 1052.4

SB-334867 (free base)

HY-10895A 10mg
EUR 258

YHO-13351 (free base)

HY-12758A 10mM/1mL
EUR 211.2

BMS-345541(free base)

B4655-10 10 mg
EUR 282
Description: BMS-345541(free base) is a selective inhibitor of IKK-1 and IKK-2 with IC50 value of 4?M and 0.3?M, respectively [1].IKK is also known as nuclear factor kappa-B kinase subunit inhibitor and involves in cytokine-activated intracellular signaling pathways.

BMS-345541(free base)

B4655-5 5 mg
EUR 205.2
Description: BMS-345541(free base) is a selective inhibitor of IKK-1 and IKK-2 with IC50 value of 4?M and 0.3?M, respectively [1].IKK is also known as nuclear factor kappa-B kinase subunit inhibitor and involves in cytokine-activated intracellular signaling pathways.

BMS-345541(free base)

B4655-50 50 mg
EUR 714
Description: BMS-345541(free base) is a selective inhibitor of IKK-1 and IKK-2 with IC50 value of 4?M and 0.3?M, respectively [1].IKK is also known as nuclear factor kappa-B kinase subunit inhibitor and involves in cytokine-activated intracellular signaling pathways.

BMS-345541 (Free base)

B1907-1 each
EUR 170.4

BMS-345541 (Free base)

B1907-5 each
EUR 496.8

RGB-286638,  free base

2886-25 each
EUR 907.2

RGB-286638,  free base

2886-5 each
EUR 274.8

L-Arginine free base

AB0205 100g
EUR 75.78

SNT-207858 (free base)

HY-11030A 10mg
EUR 1093.2

RGB-286638 (free base)

HY-15504A 100mg
EUR 3364.8

LY-2584702 (free base)

HY-12493 5mg
EUR 198

Vandetanib, >99% Free Base

BC098-025 25mg
EUR 278.4

Vandetanib, >99% Free Base

BC098-050 50mg
EUR 343.2

Vandetanib, >99% Free Base

BC098-100 100mg
EUR 375.6

Genz-123346 (free base)

HY-12744 10mM/1mL
EUR 226.8

StemRegenin 1, Free base

2642-1 each
EUR 157.2

StemRegenin 1, Free base

2642-5 each
EUR 398.4

Staurosporine, >99% Free Base

BC090-001 1mg
EUR 295.2

Staurosporine, >99% Free Base

BC090-005 5mg
EUR 408

BAY 58-2667 (Free base)

2452-1 each
EUR 424.8

BAY 58-2667 (Free base)

2452-5 each
EUR 1358.4

BAY 43-9006, Free base

2142-100 each
EUR 502.8

BAY 43-9006, Free base

2142-25 each
EUR 202.8

SB 202190, >99% Free Base

BC086-025 25mg
EUR 246

SB 202190, >99% Free Base

BC086-050 50mg
EUR 295.2

SB 203580, >99% Free Base

BC087-025 25mg
EUR 262.8

SB 203580, >99% Free Base

BC087-050 50mg
EUR 343.2

Bay 65-1942 (free base)

HY-50949 10mg
EUR 1282.8

H-Tyr-OEt (free base)

E-2900.0025 25.0g
EUR 166.8
Description: Sum Formula: C11H15NO3; CAS# [949-67-7]

H-Tyr-OEt (free base)

E-2900.0100 100.0g
EUR 428.4
Description: Sum Formula: C11H15NO3; CAS# [949-67-7]

Gastrofensin AN 5 free base

HY-100296 5mg
EUR 2544

Adenine, Free Base (Vitamin B4)

A2121-25G 25G
EUR 30.8
Description: High Purity

Adenine, Free Base (Vitamin B4)

A2121-5G 5G
EUR 13.2
Description: High Purity

biotin cadaverine, free base form

90079 50MG
EUR 258
Description: Minimum order quantity: 1 unit of 50MG

Glyoxalase I inhibitor (free base)

HY-15167A 50mg
EUR 3036

EZSolution? StemRegenin 1, Free base

2643-1 each
EUR 170.4

H-Arg(Mtr)-OtBu (free base)

E-3075.0001 1.0g
EUR 370.8
Description: Sum Formula: C20H34N4O5S; CAS# [115608-61-2]

H-Arg(Mtr)-OtBu (free base)

E-3075.0005 5.0g
EUR 1371.6
Description: Sum Formula: C20H34N4O5S; CAS# [115608-61-2]

H-Arg(Pmc)-OtBu (free base)

E-3085.0001 1.0g
EUR 501.6
Description: Sum Formula: C24H40N4O5S; CAS# [169543-81-1]

H-Arg(Pmc)-OtBu (free base)

E-3085.0005 5.0g
EUR 1864.8
Description: Sum Formula: C24H40N4O5S; CAS# [169543-81-1]

Biotin ethylenediamine (free base form)

90071 25MG
EUR 158.4
Description: Minimum order quantity: 1 unit of 25MG

biotin-x cadaverine, free base form

90080 20MG
EUR 258
Description: Minimum order quantity: 1 unit of 20MG

PNU-282987 (S enantiomer free base)

HY-12560D 5mg
EUR 1216.8

Cyclosporin A-Derivative 1 (Free base)

HY-P1355A 1mg
EUR 267.6

A830, High Capacity Weak Base Acrylic Anion Resin, Free Base Form

50226-1 1000ml
EUR 192
Description: 7732-18-5

A830, High Capacity Weak Base Acrylic Anion Resin, Free Base Form

50226-250 250ml
EUR 62
Description: 7732-18-5

CHIR 99021, GSK-3 Inhibitor , Free Base

BC212-002 2 mg
EUR 213.6

CHIR 99021, GSK-3 Inhibitor , Free Base

BC212-005 5 mg
EUR 318

CHIR 99021, GSK-3 Inhibitor , Free Base

BC212-010 10 mg
EUR 378

CHIR 99021, GSK-3 Inhibitor , Free Base

BC212-025 25 mg
EUR 472.8

CHIR 99021, GSK-3 Inhibitor , Free Base

BC212-100 100 mg
EUR 1064.4

H-Ala-Ala-Phe-AMC (free base)

I-1415.0050 50.0mg
EUR 181.2
Description: Sum Formula: C25H28N4O5; CAS# [62037-41-6]

H-Ala-Ala-Phe-AMC (free base)

I-1415.0250 250.0mg
EUR 618
Description: Sum Formula: C25H28N4O5; CAS# [62037-41-6]

(D-Ser(tBu)6,Azagly10)-LHRH (free base)

H-7296.0005 5.0mg
EUR 219.6
Description: Sum Formula: C59H84N18O14; CAS# [65807-02-5]

(D-Ser(tBu)6,Azagly10)-LHRH (free base)

H-7296.0025 25.0mg
EUR 769.2
Description: Sum Formula: C59H84N18O14; CAS# [65807-02-5]

PCR Buffer I, NH4 Based Mg & TWEEN Free

42-302 3 x 1.5ml/Unit
EUR 288

Channel Base

C653 EACH
EUR 26.4

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