Melting dsDNA Donor Molecules Vastly Improves Precision Genome Enhancing in Caenorhabditiselegans
CRISPR genome modifying has revolutionized genetics in quite a few organisms. Contained in the nematode Caenorhabditiselegans one injection into every of the 2 gonad arms of an grownup hermaphrodite exposes tons of of meiotic germ cells to modifying mixtures, allowing the restoration of quite a lot of indels or small precision edits from every successfully injected animal. Sadly, significantly for extended insertions, modifying efficiencies can differ broadly, necessitating quite a lot of injections, and usually requiring co-selection methods.
Correct proper right here we present that melting double stranded DNA (dsDNA) donor molecules earlier to injection will enhance the frequency of tangible homology-directed restore (HDR) by quite a lot of fold for longer edits.
We describe troubleshooting methods that allow persistently excessive modifying efficiencies ensuing, as an illustration, in as lots as 100 unbiased GFP knock-ins from a single injected animal. These efficiencies make C. elegans by far the most effective metazoan to genome edit, eradicating limitations to the use and adoption of this facile system as a mannequin for understanding animal biology.
An embedded gene choice methodology utilizing knockoffs optimizing neural community
Background: Gene alternative refers to find a small subset of discriminant genes from the gene expression profiles. The way in which to decide on genes that affect specific phenotypic traits efficiently is a crucial evaluation work throughout the topic of biology. The neural neighborhood has greater changing into functionality when dealing with nonlinear data, and it’ll most likely seize choices robotically and flexibly. On this work, we recommend an embedded gene alternative methodology using neural neighborhood.
The important genes could also be obtained by calculating the burden coefficient after the teaching is completed. In an effort to treatment the problem of black subject of neural neighborhood and extra make the teaching outcomes interpretable in neural neighborhood, we use the idea of knockoffs to assemble the knockoff attribute genes of the distinctive attribute genes. This system not solely make each attribute gene to compete with each other, however moreover make each attribute gene compete with its knockoff attribute gene. This methodology could assist to choose the vital factor genes that affect the decision-making of neural networks.
Outcomes: We use maize carotenoids, tocopherol methyltransferase, raffinose family oligosaccharides and human breast most cancers dataset to do verification and analysis.
Conclusions: The experiment outcomes show that the knockoffs optimizing neural neighborhood methodology has greater detection influence than the alternative current algorithms, and particularly for processing the nonlinear gene expression and phenotype data.
Fenretinide |
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T1872-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Fenretinide |
Fenretinide |
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T1872-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Fenretinide |
Fenretinide |
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T1872-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Fenretinide |
Fenretinide |
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T1872-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Fenretinide |
Fenretinide |
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T1872-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Fenretinide |
Fenretinide |
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GP8861 | Glentham Life Sciences | 10mg | EUR 101.33 |
Fenretinide |
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F250000 | Toronto Research Chemicals | 25mg | EUR 106 |
Description: 65646-68-6 |
Fenretinide |
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HY-15373 | MedChemExpress | 10mM/1mL | EUR 151.2 |
Fenretinide |
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GP8861-10 | Glentham Life Sciences | 10 | EUR 63.3 |
Fenretinide |
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GP8861-10MG | Glentham Life Sciences | 10 mg | EUR 112.8 |
Fenretinide |
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GP8861-25 | Glentham Life Sciences | 25 | EUR 110.7 |
Fenretinide |
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GP8861-25MG | Glentham Life Sciences | 25 mg | EUR 170.4 |
Fenretinide |
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MBS384058-100mg | MyBiosource | 100mg | EUR 220 |
Fenretinide |
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MBS384058-25mg | MyBiosource | 25mg | EUR 160 |
Fenretinide |
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MBS384058-50mg | MyBiosource | 50mg | EUR 180 |
Fenretinide |
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MBS384058-5x100mg | MyBiosource | 5x100mg | EUR 990 |
Fenretinide |
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MBS3605494-100mg | MyBiosource | 100mg | EUR 260 |
Fenretinide |
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MBS3605494-10mg | MyBiosource | 10mg | EUR 210 |
Fenretinide |
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MBS3605494-25mg | MyBiosource | 25mg | EUR 235 |
Fenretinide |
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MBS3605494-50mg | MyBiosource | 50mg | EUR 245 |
Fenretinide |
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MBS3605494-5mg | MyBiosource | 5mg | EUR 200 |
Fenretinide |
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MBS576264-100mg | MyBiosource | 100mg | EUR 200 |
Fenretinide |
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MBS576264-10mg | MyBiosource | 10mg | EUR 145 |
Fenretinide |
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MBS576264-25mg | MyBiosource | 25mg | EUR 170 |
Fenretinide |
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MBS576264-50mg | MyBiosource | 50mg | EUR 180 |
Fenretinide |
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MBS576264-5mg | MyBiosource | 5mg | EUR 145 |
Fenretinide-d4 |
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F250002 | Toronto Research Chemicals | 25mg | EUR 1200 |
Fenretinide-d4 |
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HY-110360 | MedChemExpress | Get quote | Ask for price |
Description: Fenretinide-d4 is the deuterium labeled Fenretinide. |
Fenretinide (4-HPR) |
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abx282632-100g | Abbexa | 100 µg | Ask for price |
Fenretinide (4-HPR) |
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abx282632-20g | Abbexa | 20 µg | EUR 143.75 |
Fenretinide (4-HPR) |
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abx282632-50g | Abbexa | 50 µg | EUR 362.5 |
3-Hydroxy Fenretinide |
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H825635 | Toronto Research Chemicals | 50mg | EUR 4500 |
Description: 1027233-22-2 |
Fenretinide [CAS# 65646-68-6] |
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F-4077 | LC LABORATORIES | 10 mg | EUR 39 |
4-Methoxy Fenretinide-13C,d3 |
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M262662 | Toronto Research Chemicals | 25mg | EUR 3000 |
Fenretinide glucuronide-d4 |
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HY-143957S | MedChemExpress | 1mg | Ask for price |
Description: Fenretinide glucuronide-d4 is the deuterium labeled Fenretinide glucuronide[1]. |
4'-Hydroxy Fenretinide-d4 |
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HY-143958S | MedChemExpress | 1mg | Ask for price |
Description: 4'-Hydroxy Fenretinide-d4 is the deuterium labeled 4'-Hydroxy Fenretinide[1]. |
3-Hydroxy Fenretinide-d4 |
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H825637 | Toronto Research Chemicals | 25mg | EUR 4500 |
4-Methoxy Fenretinide-d4 |
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M262661 | Toronto Research Chemicals | 10mg | EUR 1200 |
Fenretinide Glucuronide Monosodium Salt |
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F250010 | Toronto Research Chemicals | 500mg | EUR 11200 |
Description: 76177-99-6 |
Fenretinide (N-(4-Hydroxyphenyl)retinamide) |
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MBS6081236-10mg | MyBiosource | 10(mg | EUR 500 |
Fenretinide (N-(4-Hydroxyphenyl)retinamide) |
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MBS6081236-5x10mg | MyBiosource | 5x10mg | EUR 2090 |
Fenretinide Glucuronide Monosodium Salt-d4 |
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F250012 | Toronto Research Chemicals | 100mg | EUR 11200 |
13-cis-Fenretinide |
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F250005 | Toronto Research Chemicals | 100mg | EUR 1455 |
Description: 75686-07-6 |
13-cis-Fenretinide-d4 |
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F250007 | Toronto Research Chemicals | 25mg | EUR 1200 |
FEN1, 1-380aa, Human, E Coli |
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MBS203445-002mg | MyBiosource | 0.02mg | EUR 230 |
FEN1, 1-380aa, Human, E Coli |
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MBS203445-01mg | MyBiosource | 0.1mg | EUR 405 |
FEN1, 1-380aa, Human, E Coli |
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MBS203445-05mg | MyBiosource | 0.5mg | EUR 985 |
FEN1, 1-380aa, Human, E Coli |
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MBS203445-5x05mg | MyBiosource | 5x0.5mg | EUR 4180 |
FEN1 (NM_004111) Human Over-expression Lysate |
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LS002237 | BosterBio | 100ug | EUR 628 |
Description: Transient overexpression lysate of flap structure-specific endonuclease 1 (FEN1) |
1000 ug/mL Fenthion in Acetone - 1ML |
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S-2010-AC | Scientific Laboratory Supplies | 1ML | EUR 189 |
1000 ug/mL Fenobucarb in Acetone - 1ML |
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S-4610-AC | Scientific Laboratory Supplies | 1ML | EUR 106.65 |
FEN1 |
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CSB-CL008585HU | Cusabio | 10 μg plasmid + 200μl Glycerol | Ask for price |
FEN1 |
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enz-468 | ProSpec Tany | 5µg | EUR 60 |
Description: Recombinant Human Flap Structure-Specific Endonuclease 1 |
FEN1 |
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MBS8561543-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
FEN1 |
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MBS8561543-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
FEN1 |
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MBS8561543-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
FEN1 |
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MBS8561543-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
FEN1 |
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MBS8561543-02mL | MyBiosource | 0.2mL | EUR 345 |
1000 ug/mL Fenpyroximate in Acetone - 1ML |
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S-5804 | Scientific Laboratory Supplies | 1ML | EUR 259.2 |
Lenti ORF particles, Fen1 (GFP-tagged) - Mouse flap structure specific endonuclease 1 (Fen1), 200ul, >10^7 TU/mL |
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MR220960L4V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, Fen1 (GFP-tagged ORF) - Rat flap structure-specific endonuclease 1 (Fen1), 200ul, >10^7 TU/mL |
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RR207787L4V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, Fen1 (Myc-DDK-tagged) - Mouse flap structure specific endonuclease 1 (Fen1), 200ul, >10^7 TU/mL |
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MR220960L3V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, FEN1 (Myc-DDK tagged) - Human flap structure-specific endonuclease 1 (FEN1), 200ul, >10^7 TU/mL |
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RC201785L1V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, FEN1 (mGFP-tagged) - Human flap structure-specific endonuclease 1 (FEN1), 200ul, >10^7 TU/mL |
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RC201785L2V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, FEN1 (Myc-DDK tagged) - Human flap structure-specific endonuclease 1 (FEN1), 200ul, >10^7 TU/mL |
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RC201785L3V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, FEN1 (mGFP-tagged) - Human flap structure-specific endonuclease 1 (FEN1), 200ul, >10^7 TU/mL |
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RC201785L4V | Origene Technologies GmbH | 200 µl | Ask for price |
FEN1 siRNA |
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20-abx916746 | Abbexa |
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FEN1 siRNA |
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20-abx916747 | Abbexa |
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FEN1-IN-2 |
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T40931-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: FEN1-IN-2 |
FEN1-IN-2 |
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T40931-1g | TargetMol Chemicals | 1g | Ask for price |
Description: FEN1-IN-2 |
FEN1-IN-2 |
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T40931-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: FEN1-IN-2 |
FEN1-IN-2 |
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T40931-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: FEN1-IN-2 |
FEN1-IN-2 |
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T40931-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: FEN1-IN-2 |
FEN1-IN-3 |
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T9147-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: FEN1-IN-3 |
FEN1-IN-3 |
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T9147-1g | TargetMol Chemicals | 1g | Ask for price |
Description: FEN1-IN-3 |
FEN1-IN-3 |
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T9147-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: FEN1-IN-3 |
FEN1-IN-3 |
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T9147-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: FEN1-IN-3 |
FEN1-IN-3 |
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T9147-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: FEN1-IN-3 |
FEN1-IN-1 |
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T15274-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: FEN1-IN-1 |
FEN1-IN-1 |
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T15274-1g | TargetMol Chemicals | 1g | Ask for price |
Description: FEN1-IN-1 |
FEN1-IN-1 |
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T15274-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: FEN1-IN-1 |
FEN1-IN-1 |
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T15274-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: FEN1-IN-1 |
FEN1-IN-1 |
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T15274-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: FEN1-IN-1 |
FEN1-IN-4 |
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T8545-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: FEN1-IN-4 |
FEN1-IN-4 |
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T8545-1g | TargetMol Chemicals | 1g | Ask for price |
Description: FEN1-IN-4 |
FEN1-IN-4 |
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T8545-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: FEN1-IN-4 |
FEN1-IN-4 |
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T8545-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: FEN1-IN-4 |
FEN1-IN-4 |
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T8545-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: FEN1-IN-4 |
FEN1-IN-2 |
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MBS5801085-5mg | MyBiosource | 5(mg | EUR 915 |
FEN1-IN-2 |
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MBS5801085-5x5mg | MyBiosource | 5x5(mg | EUR 3970 |
FEN1-IN-1 |
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MBS133109-INQUIRE | MyBiosource | INQUIRE | Ask for price |
FEN1-IN-1 |
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MBS5754862-10mg | MyBiosource | 10mg | EUR 170 |
FEN1-IN-1 |
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MBS5754862-25mg | MyBiosource | 25mg | EUR 195 |
FEN1-IN-1 |
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MBS5754862-2mg | MyBiosource | 2mg | EUR 145 |
FEN1-IN-1 |
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MBS5754862-50mg | MyBiosource | 50mg | EUR 240 |
FEN1-IN-1 |
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MBS5754862-5mg | MyBiosource | 5mg | EUR 150 |
FEN1-IN-5 |
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HY-153790 | MedChemExpress | 10 mg | EUR 308.45 |
Description: FEN1-IN-5 (compound 12A) is a potent inhibitor of Flap endonuclease-1 (FEN1, IC50=12 nM), involving in DNA repair[1]. |
FEN1-IN-6 |
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HY-153791 | MedChemExpress | Get quote | Ask for price |
Description: FEN1-IN-6 (compound 9) is a potent inhibitor of Flap endonuclease-1 (FEN1, IC50=10 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-6 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 23 nM[1]. |
FEN1-IN-7 |
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HY-153792 | MedChemExpress | Get quote | Ask for price |
Description: FEN1-IN-7 (compound 16) is a selective inhibitor of Flap endonuclease-1 (FEN1, IC50=18 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-7 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 3.04 μM. FEN1-IN-7 increases the cellular sensitivity of cancer cells to potent DNA alkylating agents or methylating agents[1]. |
FEN1-IN-2 |
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HY-122695 | MedChemExpress | 10 mg | EUR 1028.15 |
Description: FEN1-IN-2 (compound 20) is a flap endonuclease 1 (FEN1) inhibitor, with IC50 values of 3 nM and 226 nM for FEN1 and XPG, respectively[1]. |
FEN1-IN-1 |
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HY-123834 | MedChemExpress | 1 mg | EUR 205.63 |
Description: FEN1-IN-1 (compound 1) is a flap endonuclease 1 (FEN1) inhibitor. FEN1-IN-1 binds to the active site of FEN1 and partly achieves inhibition by the co-ordination of Mg2+ ions[1]. |
FEN1-IN-3 |
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HY-136484 | MedChemExpress | 10 mg | EUR 487.02 |
Description: FEN1-IN-3 (Compound 4) is a human flap endonuclease-1 (hFEN1) inhibitor. FEN1-IN-3 stabilizes hFEN1 with an EC50 of 6.8 μM[1]. |
FEN1-IN-4 |
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HY-136485 | MedChemExpress | 1 mg | EUR 535.72 |
Description: FEN1-IN-4 (Compound 2) is a human flap endonuclease-1 (hFEN1) inhibitor[1]. |
1000 ug/mL Fenamidone in HPLC Acetonitrile - 1ML |
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LCS-4966 | Scientific Laboratory Supplies | 1ML | EUR 390.15 |
1000 ug/mL Fenazaquin in HPLC Acetonitrile - 1ML |
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LCS-6019 | Scientific Laboratory Supplies | 1ML | EUR 398.25 |
1000 ug/mL of Fenitrothion in Acetone 1mL Ampule - 1ML |
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S-2001 | Scientific Laboratory Supplies | 1ML | EUR 67.5 |
Fen1 (untagged ORF) - Rat flap structure-specific endonuclease 1 (Fen1), (10 ug) |
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RN207787 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF particles, Fen1 (Myc-DDK-tagged ORF) - Rat flap structure-specific endonuclease 1 (Fen1), 200ul, >10^7 TU/mL |
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RR207787L3V | Origene Technologies GmbH | 200 µl | Ask for price |
Fen1 (GFP-tagged) - Mouse flap structure specific endonuclease 1 (Fen1), (10ug) |
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MG220960 | Origene Technologies GmbH | 10 µg | Ask for price |
Fen1 (untagged) - Mouse flap structure specific endonuclease 1 (Fen1), (10ug) |
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MC208478 | Origene Technologies GmbH | 10 µg | Ask for price |
FEN1 (GFP-tagged) - Human flap structure-specific endonuclease 1 (FEN1) |
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RG201785 | Origene Technologies GmbH | 10 µg | Ask for price |
FEN1 (untagged)-Human flap structure-specific endonuclease 1 (FEN1) |
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SC110892 | Origene Technologies GmbH | 10 µg | Ask for price |
1000 ug/mL (E)-Fenpyroximate in Acetonitrile - 1ML |
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S-6179 | Scientific Laboratory Supplies | 1ML | EUR 136.35 |
FEN1 siRNA (Rat) |
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MBS8223612-15nmol | MyBiosource | 15nmol | EUR 405 |
FEN1 siRNA (Rat) |
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MBS8223612-30nmol | MyBiosource | 30nmol | EUR 565 |
FEN1 siRNA (Rat) |
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MBS8223612-5x30nmol | MyBiosource | 5x30nmol | EUR 2450 |
FEN-1 mouse mAb |
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UB-GEN-1074 | UpingBio | 100 ul | EUR 200 |
FEN-1 mouse mAb |
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UB-GEN-1075 | UpingBio | 100 ul | EUR 200 |
Fen1 (Myc-DDK-tagged) - Mouse flap structure specific endonuclease 1 (Fen1) |
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MR220960 | Origene Technologies GmbH | 10 µg | Ask for price |
Fen1 (Myc-DDK-tagged ORF) - Rat flap structure-specific endonuclease 1 (Fen1), (10 ug) |
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RR207787 | Origene Technologies GmbH | 10 µg | Ask for price |
FEN1 Rabbit mAb |
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59492 | SAB | 100ul | EUR 339 |
FEN1 Rabbit mAb |
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52758 | SAB | 100ul | EUR 499 |
FEN1 Rabbit pAb |
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A1175-200ul | Abclonal | 200 ul | EUR 550.8 |
FEN1 Rabbit pAb |
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A1175-20ul | Abclonal | 20 ul | EUR 219.6 |
FEN-1 Rabbit mAb |
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A8999 | Abclonal | 20 μL | EUR 128.7 |
Description: A synthetic peptide corresponding to a sequence within amino acids 5000-5100 of human MUC2 (Q02817). |
FEN1 protein |
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30R-1442 | Fitzgerald | 100 ug | EUR 410 |
Description: Purified recombinant Human FEN1 protein |
FEN1 Rabbit pAb |
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E2381904 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
FEN1 Rabbit mAb |
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E2R26747 | EnoGene | 100ul | EUR 255 |
Description: Available in various conjugation types. |
FEN1 Rabbit pAb |
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E2501175 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
FEN1 Rabbit pAb |
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A0129-100ul | Abclonal | 100 ul | EUR 369.6 |
FEN1 Rabbit pAb |
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A0129-200ul | Abclonal | 200 ul | EUR 550.8 |
FEN1 Rabbit pAb |
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A0129-20ul | Abclonal | 20 ul | Ask for price |
FEN1 Rabbit pAb |
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A0129-50ul | Abclonal | 50 ul | Ask for price |
FEN1 cDNA Clone |
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MBS1271477-001mgPlasmid02mLGlycerolStock | MyBiosource | 0.01mgPlasmid+0.2mLGlycerol-Stock | EUR 200 |
FEN1 cDNA Clone |
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MBS1271477-5x001mgPlasmid5x02mLGlycerolStock | MyBiosource | 5x0.01mgPlasmid+5x0.2mLGlycerol-Stock | EUR 855 |
Rat Fen1 ELISA Kit |
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ELI-27513r | Nova Lifetech | 96tests | EUR 756 |
Rat Fen1 ELISA Kit |
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EF018699 | Nova Lifetech | 96tests | EUR 566 |
FEN1 Rabbit mAb |
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E2R381904 | EnoGene | 100ul | EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
FEN1 Rabbit pAb |
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MBS8543368-01mL | MyBiosource | 0.1mL | EUR 305 |
FEN1 Rabbit pAb |
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MBS8543368-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
FEN1 Rabbit pAb |
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MBS8543368-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
FEN1 Rabbit pAb |
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MBS8543368-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
FEN1 Rabbit pAb |
|||
MBS8543368-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
FEN1 Rabbit pAb |
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MBS8544285-01mL | MyBiosource | 0.1mL | EUR 305 |
FEN1 Rabbit pAb |
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MBS8544285-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
FEN1 Rabbit pAb |
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MBS8544285-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
FEN1 Rabbit pAb |
|||
MBS8544285-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
FEN1 Rabbit pAb |
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MBS8544285-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
FEN1 Rabbit mAb |
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MBS4753269-01mL | MyBiosource | 0.1mL | EUR 450 |
FEN1 Rabbit mAb |
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MBS4753269-5x01mL | MyBiosource | 5x0.1mL | EUR 1540 |
FEN1 Peptide |
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MBS3233014-01mg | MyBiosource | 0.1mg | EUR 180 |
FEN1 Peptide |
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MBS3233014-5x01mg | MyBiosource | 5x0.1mg | EUR 730 |
FEN1 Rabbit mAb |
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MBS9467471-005mL | MyBiosource | 0.05mL | EUR 290 |
FEN1 Rabbit mAb |
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MBS9467471-01mL | MyBiosource | 0.1mL | EUR 435 |
FEN1 Rabbit mAb |
|||
MBS9467471-5x01mL | MyBiosource | 5x0.1mL | EUR 1810 |
FEN-1 Rabbit pAb |
|||
A1175 | Abclonal | 200μL | EUR 173.58 |
FEN-1 Rabbit pAb |
|||
A0129 | Abclonal | 200μL | EUR 173.58 |
1000 ug/mL (E)-Fenpyroximate in HPLC Acetonitrile - 1ML |
|||
LCS-6179 | Scientific Laboratory Supplies | 1ML | EUR 398.25 |
1000 ug/mL Fenpyroximate in HPLC Acetonitrile - 1ML |
|||
LCS-6387 | Scientific Laboratory Supplies | 1ML | EUR 218.7 |
1000 ug/mL Fenthion sulfoxide in Acetonitrile - 1ML |
|||
S-4316-ACN | Scientific Laboratory Supplies | 1ML | EUR 125.55 |
FEN1 (Myc-DDK-tagged)-Human flap structure-specific endonuclease 1 (FEN1) |
|||
RC201785 | Origene Technologies GmbH | 10 µg | Ask for price |
FEN1 Antibody |
|||
8C10585 | AAT Bioquest | 50ug | EUR 368 |
Description: FEN1 Antibody |
FEN1 antibody |
|||
10R-1738 | Fitzgerald | 100 ug | EUR 614.4 |
Description: Mouse monoclonal FEN1 antibody |
FEN1 Antibody |
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32204 | SAB | 100ul | EUR 439 |
FEN1 Antibody |
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32204-100ul | SAB | 100ul | EUR 302.4 |
FEN1 Antibody |
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33763 | SAB | 100ul | EUR 319 |
FEN1 Antibody |
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33763-100ul | SAB | 100ul | EUR 302.4 |
FEN1 Antibody |
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33763-50ul | SAB | 50ul | EUR 224.4 |
FEN1 Antibody |
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CSB-PA926648- | Cusabio | each | EUR 402 |
Description: A polyclonal antibody against FEN1. Recognizes FEN1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 |
FEN1 Antibody |
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CSB-PA926648-100ul | Cusabio | 100ul | EUR 379.2 |
Description: A polyclonal antibody against FEN1. Recognizes FEN1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 |
FEN1 Antibody |
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E033763 | EnoGene | 100μg/100μl | EUR 255 |
Description: Available in various conjugation types. |
FEN1 Antibody |
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E11-10585C | EnoGene | 100μg | EUR 225 |
Description: Available in various conjugation types. |
FEN1 Antibody |
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E19-3172 | EnoGene | 100μg/100μl | EUR 225 |
Description: Available in various conjugation types. |
FEN1 Antibody |
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E19-6309 | EnoGene | 100μg/100μl | EUR 225 |
Description: Available in various conjugation types. |
FEN1 Antibody |
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DF6309 | Affbiotech | 200ul | EUR 420 |
FEN1 Antibody |
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DF6309-100ul | Affinity Biosciences | 100ul | EUR 280 |
FEN1 Antibody |
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DF6309-200ul | Affinity Biosciences | 200ul | EUR 350 |
FEN1 Antibody |
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DF3172 | Affbiotech | 200ul | EUR 420 |
FEN1 Antibody |
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E91175 | EnoGene | 100ul | EUR 255 |
Description: Available in various conjugation types. |
FEN1 Antibody |
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E38PA1417 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
FEN1 Antibody |
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E309179 | EnoGene | 200ul | EUR 275 |
Description: Available in various conjugation types. |
FEN1 Antibody |
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CAC11682-100ul | Biomatik Corporation | 100ul | EUR 314 |
FEN1 Antibody |
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CAC11682-50ul | Biomatik Corporation | 50ul | EUR 199.2 |
FEN1 antibody |
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70R-1605 | Fitzgerald | 100 ug | EUR 407 |
Description: Rabbit polyclonal FEN1 antibody raised against the C terminal of FEN1 |
FEN1 antibody |
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70R-17281 | Fitzgerald | 50 ul | EUR 289 |
Description: Rabbit polyclonal FEN1 antibody |
FEN1 antibody |
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70R-31706 | Fitzgerald | 100 ug | EUR 294 |
Description: Rabbit polyclonal FEN1 antibody |
FEN1 antibody |
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70R-49736 | Fitzgerald | 100 ul | EUR 242 |
Description: Purified Polyclonal FEN1 antibody |
FEN1 Antibody |
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1-CSB-PA008585GA01HU | Cusabio |
|
|
Description: A polyclonal antibody against FEN1. Recognizes FEN1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB |
FEN1 Antibody |
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CSB-PA008585KA01HU- | Cusabio | each | EUR 402 |
Description: A polyclonal antibody against FEN1. Recognizes FEN1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200 |
FEN1 Antibody |
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CSB-PA008585KA01HU-100ul | Cusabio | 100ul | EUR 466.8 |
Description: A polyclonal antibody against FEN1. Recognizes FEN1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200 |
FEN1 Antibody |
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1-CSB-PA002510 | Cusabio |
|
|
Description: A polyclonal antibody against FEN1. Recognizes FEN1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/20000 |
FEN1-IN-SC13 |
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T9743-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: FEN1-IN-SC13 |
FEN1-IN-SC13 |
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T9743-1g | TargetMol Chemicals | 1g | Ask for price |
Description: FEN1-IN-SC13 |
FEN1-IN-SC13 |
|||
T9743-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: FEN1-IN-SC13 |
FEN1-IN-SC13 |
|||
T9743-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: FEN1-IN-SC13 |
Single cell transcriptomes reveal expression patterns of chemoreceptor genes in olfactory sensory neurons of the Caribbean spiny lobster, Panulirus argus
Background: Crustaceans categorical various programs of receptor genes of their antennules, which house olfactory sensory neurons (OSNs) and non-olfactory chemosensory neurons. Transcriptomics analysis reveal that candidate chemoreceptor proteins embrace variant Ionotropic Receptors (IRs) along with every co-receptor IRs and tuning IRs, Transient Receptor Potential (TRP) channels, Gustatory Receptors, epithelial sodium channels, and class A G-protein coupled receptors (GPCRs). The Caribbean spiny lobster, Panulirus argus, expresses in its antennules nearly 600 IRs, 17 TRP channels, 1 Gustatory Receptor, 7 epithelial sodium channels, 81 GPCRs, 6 G proteins, and dozens of enzymes in signaling pathways.
Nonetheless, the exact combinatorial expression patterns of these proteins in single sensory neurons often are usually not acknowledged for any crustacean, limiting our understanding of how their chemosensory methods encode chemical top quality.
Outcomes: The aim of this analysis was to utilize transcriptomics to elucidate expression patterns of chemoreceptor genes in OSNs of P. argus. We generated and analyzed transcriptomes from 7 single OSNs, a couple of of which have been confirmed to reply a meals odor, along with an additional 7 multicell transcriptomes from preparations containing few (2-4), various (ca. 15), or many (ca. 400) OSNs.
We found that each OSN expressed the an identical 2 co-receptor IRs (IR25a, IR93a) nonetheless not the alternative 2 antennular coIRs (IR8a, IR76b), 9-53 tuning IRs nonetheless only one to some in extreme abundance, the an identical 5 TRP channels plus as a lot as 5 further TRPs, 12-17 GPCRs along with the an identical 5 expressed in every single cell transcriptome, the an identical Three G proteins plus others, many enzymes throughout the signaling pathways, nonetheless no Gustatory Receptors or epithelial sodium channels. The perfect distinction in receptor expression among the many many OSNs was the identification of the tuning IRs.
Conclusions: Our outcomes current an preliminary view of the combinatorial expression patterns of receptor molecules in single OSNs in a single species of decapod crustacean, along with receptors straight involved in olfactory transduction and others likely involved in modulation. Our outcomes moreover counsel variations in receptor expression in OSNs vs. totally different chemosensory neurons.
Camel Genetic Property Conservation by Tourism: A Key Sociocultural Methodology of Camelback Leisure Driving
- Camels are distinctive elements, which can be comprised inside journey journey companies promoting ecotourism actions. Such recreations contribute to sustainable livelihoods for native communities and educational empowerment within the route of nature and its conservation.
- At present, some native camel breeds’ survival reduces to this animal-based leisure enterprise and its reliability to hold out and promote custom-made corporations By conducting an on-site questionnaire to prospects collaborating in camelback driving excursions, we assessed the motivational elements affecting participation, satisfaction, and loyalty on this tourism section that can have made it socially differentiated.
- The sixfold combination of staff effectivity, custom geography, quite a few and humane shut interaction, camel conduct and effectivity, sociotemporal context, and constructive earlier experience consists of the elemental dimensions that designate purchaser satisfaction and return intention likelihood inside this leisure enterprise.
- Purchaser knowledge is essential for stakeholders to assemble personalised driving experiences and align earnings with environmental sustainability and biodiversity mainstream issues into their regularly operations. In flip, house camel vacationer rides could be managed as a viable path to nature conservation by serving to endangered native breeds to steer clear of their helpful devaluation and potential extinction.
Afatinib free base |
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MBS5756697-10mg | MyBiosource | 10mg | EUR 145 |
Afatinib free base |
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MBS5756697-200mg | MyBiosource | 200mg | EUR 250 |
Afatinib free base |
|||
MBS5756697-50mg | MyBiosource | 50mg | EUR 195 |
Afatinib free base |
|||
MBS5756697-5x200mg | MyBiosource | 5x200mg | EUR 965 |
Afatinib, Free Base [CAS# 850140-72-6] |
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A-8644 | LC LABORATORIES | 25 mg | EUR 46 |
Afatinib |
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27009 | BPS Bioscience | 25 mg | EUR 115 |
Description: Afatinib, also known as BIW-2992, is an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinases. Afatinib suppresses EGF-induced EGFR phosphorylation and cellular proliferation in various cell lines, including EGFR-overexpressing and HER2-expressing cell lines A431, NIH-3T3-HER2, NCI-N87 and BT-474. |
Afatinib |
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A355300 | Toronto Research Chemicals | 100mg | EUR 68 |
Description: 850140-72-6 |
Afatinib |
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A170-100MG | TOKU-E | 100mg | EUR 62.04 |
Description: C24H25ClFN5O3 |
Afatinib |
|||
GW6150 | Glentham Life Sciences | 1mg | EUR 395.63 |
Afatinib |
|||
GW6150-1 | Glentham Life Sciences | 1 | EUR 171.5 |
Afatinib |
|||
GW6150-10 | Glentham Life Sciences | 10 | EUR 368.2 |
Afatinib |
|||
GW6150-5 | Glentham Life Sciences | 5 | EUR 237.4 |
Afatinib |
|||
HY-10261 | MedChemExpress | 200mg | EUR 374.4 |
Afatinib |
|||
T21312-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Afatinib |
Afatinib |
|||
T21312-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Afatinib |
Afatinib |
|||
T21312-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Afatinib |
Afatinib |
|||
T21312-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Afatinib |
Afatinib |
|||
T21312-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Afatinib |
Afatinib |
|||
MBS3842612-100mg | MyBiosource | 100mg | EUR 425 |
Afatinib |
|||
MBS3842612-10mg | MyBiosource | 10mg | EUR 140 |
Afatinib |
|||
MBS3842612-25mg | MyBiosource | 25mg | EUR 200 |
Afatinib |
|||
MBS3842612-50mg | MyBiosource | 50mg | EUR 275 |
Afatinib |
|||
MBS3842612-5x100mg | MyBiosource | 5x100mg | EUR 1910 |
Afatinib |
|||
MBS3604489-10mg | MyBiosource | 10mg | EUR 260 |
Afatinib |
|||
MBS3604489-25mg | MyBiosource | 25mg | EUR 325 |
Afatinib |
|||
MBS3604489-2mg | MyBiosource | 2mg | EUR 200 |
Afatinib |
|||
MBS3604489-50mg | MyBiosource | 50mg | EUR 435 |
Afatinib |
|||
MBS3604489-5mg | MyBiosource | 5mg | EUR 215 |
(R)-Afatinib |
|||
C597485 | Toronto Research Chemicals | 10mg | EUR 969 |
Description: 945553-91-3 |
(2Z)-Afatinib |
|||
A355305 | Toronto Research Chemicals | 0.5mg | EUR 2113 |
Description: 1680184-59-1 |
Afatinib D6 |
|||
T10256-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Afatinib D6 |
Afatinib D6 |
|||
T10256-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Afatinib D6 |
Afatinib D6 |
|||
T10256-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Afatinib D6 |
Afatinib D6 |
|||
T10256-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Afatinib D6 |
Afatinib D6 |
|||
T10256-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Afatinib D6 |
(R)-Afatinib |
|||
HY-10261E | MedChemExpress | Get quote | Ask for price |
Description: (R)-Afatinib ((R)-BIBW 2992) is the Afatinib isomer. Afatinib (HY-10261) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer[1]. |
Afatinib-d4 |
|||
A355302 | Toronto Research Chemicals | 25mg | EUR 15000 |
Afatinib-d6 |
|||
A355303 | Toronto Research Chemicals | 10mg | EUR 628 |
Description: 1313874-96-2 |
Afatinib-d6 |
|||
HY-10261S | MedChemExpress | 1 mg | EUR 616.89 |
Description: Afatinib-d6 is deuterium labeled Afatinib. Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor[1]. |
Afatinib-d4 |
|||
HY-10261S1 | MedChemExpress | 1mg | Ask for price |
Description: Afatinib-d4 is the deuterium labeled Afatinib. Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. |
Afatinib Dimer |
|||
A355310 | Toronto Research Chemicals | 25mg | EUR 12800 |
Afatinib oxalate |
|||
T64075-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Afatinib oxalate |
Afatinib oxalate |
|||
T64075-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Afatinib oxalate |
Afatinib oxalate |
|||
T64075-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Afatinib oxalate |
Afatinib oxalate |
|||
T64075-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Afatinib oxalate |
Afatinib oxalate |
|||
T64075-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Afatinib oxalate |
Afatinib (oxalate) |
|||
HY-10261D | MedChemExpress | Get quote | Ask for price |
Description: Afatinib (BIBW 2992) oxalate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib oxalate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer[1][2][3][4]. |
Afatinib (BIBW2992) |
|||
A8247-10 | ApexBio | 10 mg | EUR 62 |
Description: Irreversible EGFR/HER2 inhibitor |
Afatinib (BIBW2992) |
|||
A8247-5 | ApexBio | 5 mg | EUR 37 |
Description: Irreversible EGFR/HER2 inhibitor |
Afatinib (BIBW2992) |
|||
A8247-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 55 |
Description: Irreversible EGFR/HER2 inhibitor |
Afatinib (BIBW2992) |
|||
A8247-50 | ApexBio | 50 mg | EUR 86 |
Description: Irreversible EGFR/HER2 inhibitor |
Afatinib (BIBW2992) |
|||
A8247-S | ApexBio | Evaluation Sample | EUR 22 |
Description: Irreversible EGFR/HER2 inhibitor |
Afatinib (BIBW2992) |
|||
MBS578066-10mg | MyBiosource | 10mg | EUR 195 |
Afatinib (BIBW2992) |
|||
MBS578066-25mg | MyBiosource | 25mg | EUR 260 |
Afatinib (BIBW2992) |
|||
MBS578066-2mg | MyBiosource | 2mg | EUR 145 |
Afatinib (BIBW2992) |
|||
MBS578066-50mg | MyBiosource | 50mg | EUR 370 |
Afatinib (BIBW2992) |
|||
MBS578066-5mg | MyBiosource | 5mg | EUR 155 |
BIBW2992 (Afatinib) |
|||
MBS386306-100mg | MyBiosource | 100mg | EUR 285 |
BIBW2992 (Afatinib) |
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MBS386306-10mg | MyBiosource | 10mg | EUR 140 |
BIBW2992 (Afatinib) |
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MBS386306-1mLinDMSO | MyBiosource | 1mL(inDMSO) | EUR 140 |
BIBW2992 (Afatinib) |
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MBS386306-25mg | MyBiosource | 25mg | EUR 160 |
BIBW2992 (Afatinib) |
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MBS386306-5mg | MyBiosource | 5mg | EUR 130 |
Afatinib dimaleate |
|||
120204 | MedKoo Biosciences | 100.0mg | EUR 90 |
Afatinib Dimaleate |
|||
A355315 | Toronto Research Chemicals | 1g | EUR 126 |
Description: 850140-73-7 |
Afatinib dimaleate |
|||
A3145-10 | ApexBio | 10 mg | EUR 54 |
Description: EGFR inhibitor |
Afatinib dimaleate |
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A3145-5 | ApexBio | 5 mg | EUR 33 |
Description: EGFR inhibitor |
Afatinib dimaleate |
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A3145-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 48 |
Description: EGFR inhibitor |
Afatinib dimaleate |
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A3145-50 | ApexBio | 50 mg | EUR 78 |
Description: EGFR inhibitor |
Afatinib Dimaleate |
|||
T1773-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Afatinib Dimaleate |
Afatinib Dimaleate |
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T1773-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Afatinib Dimaleate |
Afatinib Dimaleate |
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T1773-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Afatinib Dimaleate |
Afatinib Dimaleate |
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T1773-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Afatinib Dimaleate |
Afatinib Dimaleate |
|||
T1773-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Afatinib Dimaleate |
Afatinib (dimaleate) |
|||
HY-10261A | MedChemExpress | 200mg | EUR 374.4 |
Afatinib dimaleate |
|||
MBS3840747-100mg | MyBiosource | 100mg | EUR 240 |
Afatinib dimaleate |
|||
MBS3840747-25mg | MyBiosource | 25mg | EUR 165 |
Afatinib dimaleate |
|||
MBS3840747-50mg | MyBiosource | 50mg | EUR 200 |
Afatinib dimaleate |
|||
MBS3840747-5x100mg | MyBiosource | 5x100mg | EUR 1065 |
Afatinib dimaleate |
|||
MBS3606168-100mg | MyBiosource | 100mg | EUR 275 |
Afatinib dimaleate |
|||
MBS3606168-10mg | MyBiosource | 10mg | EUR 210 |
Afatinib dimaleate |
|||
MBS3606168-200mg | MyBiosource | 200mg | EUR 320 |
Afatinib dimaleate |
|||
MBS3606168-25mg | MyBiosource | 25mg | EUR 225 |
Afatinib dimaleate |
|||
MBS3606168-50mg | MyBiosource | 50mg | EUR 250 |
(E/Z)-Afatinib |
|||
HY-10261B | MedChemExpress | 100 mg | EUR 54.11 |
Description: (E/Z)-Afatinib ((E/Z)-BIBW 2992) is the mixture of (E)-Afatinib and (Z)-Afatinib. Afatinib (HY-10261) is an irreversible inhibitor of EGFR, by irreversibly binding to their ATP binding site to block activation of EGFR, HER2, HER4, and EGFRvIII. Afatinib used in co-administration with Temozolomide (HY-17364), potently targeting to EGFRvIII-cMet signaling in glioblastoma cells[1]. |
BIBW 2992 (Afatinib) |
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abx283009-100g | Abbexa | 100 µg | Ask for price |
BIBW 2992 (Afatinib) |
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abx283009-20g | Abbexa | 20 µg | EUR 156.25 |
BIBW 2992 (Afatinib) |
|||
abx283009-50g | Abbexa | 50 µg | EUR 387.5 |
(2Z)-Afatinib-d6 |
|||
A355307 | Toronto Research Chemicals | 25mg | EUR 3000 |
Afatinib N-Oxide |
|||
A355330 | Toronto Research Chemicals | 25mg | EUR 1722 |
Afatinib N-Oxide |
|||
T10257-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Afatinib N-Oxide |
Afatinib N-Oxide |
|||
T10257-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Afatinib N-Oxide |
Afatinib N-Oxide |
|||
T10257-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Afatinib N-Oxide |
Afatinib N-Oxide |
|||
T10257-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Afatinib N-Oxide |
Afatinib N-Oxide |
|||
T10257-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Afatinib N-Oxide |
Afatinib N-Oxide |
|||
HY-133110 | MedChemExpress | Get quote | Ask for price |
Description: Afatinib N-Oxide is an impurity of Afatinib dimaleate in oxidative degradation. Afatinib dimaleate is an irreversible EGFR family inhibitor[1]. |
Afatinib impurity 11 |
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T35430-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: Afatinib impurity 11 |
Afatinib impurity 11 |
|||
T35430-1g | TargetMol Chemicals | 1g | Ask for price |
Description: Afatinib impurity 11 |
Afatinib impurity 11 |
|||
T35430-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: Afatinib impurity 11 |
Afatinib impurity 11 |
|||
T35430-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: Afatinib impurity 11 |
Afatinib impurity 11 |
|||
T35430-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: Afatinib impurity 11 |
Afatinib impurity 11 |
|||
MBS5796779-1mg | MyBiosource | 1(mg | EUR 185 |
Afatinib impurity 11 |
|||
MBS5796779-5mg | MyBiosource | 5(mg | EUR 345 |
Afatinib impurity 11 |
|||
MBS5796779-5x5mg | MyBiosource | 5x5(mg | EUR 1410 |
Afatinib impurity 11 |
|||
HY-133780 | MedChemExpress | 1 mg | EUR 1439.42 |
Description: Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively[1]. |
3-Dechloro Afatinib |
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D226460 | Toronto Research Chemicals | 250mg | EUR 3000 |
Afatinib-d6 Dimaleate |
|||
A355317 | Toronto Research Chemicals | 10mg | EUR 437 |
Afatinib-d6 (dimaleate) |
|||
HY-10261AS | MedChemExpress | 1mg | Ask for price |
Description: Afatinib-d6 (dimaleate) is the deuterium labeled Afatinib dimaleate. Afatinib dimaleate is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively[1][2]. |
Afatinib (BIBW2992) Dimaleate |
|||
MBS577991-100mg | MyBiosource | 100mg | EUR 215 |
Afatinib (BIBW2992) Dimaleate |
|||
MBS577991-10mg | MyBiosource | 10mg | EUR 145 |
Afatinib (BIBW2992) Dimaleate |
|||
MBS577991-200mg | MyBiosource | 200mg | EUR 255 |
Afatinib (BIBW2992) Dimaleate |
|||
MBS577991-25mg | MyBiosource | 25mg | EUR 165 |
Afatinib (BIBW2992) Dimaleate |
|||
MBS577991-5mg | MyBiosource | 5mg | EUR 145 |
Afatinib Impurity AFT-8 |
|||
A355335 | Toronto Research Chemicals | 100mg | EUR 1028 |
Description: 2323570-72-3 |
N3-(3-Dimethylamino,1-carboxyprop-2-yl) Afatinib |
|||
D471315 | Toronto Research Chemicals | 25mg | EUR 11200 |
EGFR/HER2 kinase inhibitor (>99%, M.wt 485.94) (Afatinib/BIBW-2992 |
|||
SM-101000-5 | Alpha Diagnostics | 5 mg | EUR 196.8 |
EGFR/HER2 kinase inhibitor (>99%, M.wt 485.94) (Afatinib/BIBW-2992 |
|||
SM-101000-50 | Alpha Diagnostics | 50 mg | EUR 781.2 |
Diethyl (S)-2-Amino-2-oxoethyl Phosphonate Afatinib |
|||
D355300 | Toronto Research Chemicals | 250mg | EUR 800 |
Description: 618061-76-0 |
Des(N,N-Dimethylprop-2-enyl-1-Amine) Afatinib |
|||
D291240 | Toronto Research Chemicals | 10mg | EUR 1631 |
3-Dechloro-4-defluoro 4-Chloro-3-fluoro Afatinib |
|||
D226455 | Toronto Research Chemicals | 100mg | EUR 3000 |
Deschloro-N-des(4-dimethylamino-2-en-1-oxo)butyl Afatinib |
|||
D289625 | Toronto Research Chemicals | 1g | EUR 1800 |
Desfluoro-N-des(4-dimethylamino-2-en-1-oxo)butyl Afatinib |
|||
D289815 | Toronto Research Chemicals | 2.5g | EUR 1800 |
Description: 2413212-09-4 |
Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl (Contained ~8.5% Ethanol) |
|||
A355320 | Toronto Research Chemicals | 100mg | EUR 276 |
Description: 314771-76-1 |
Deschloro,desfluoro-N-des(4-dimethylamino-2-en-1-oxo)butyl Afatinib |
|||
D289635 | Toronto Research Chemicals | 2.5g | EUR 1800 |
Des-(4-dimethylamino-2-en-1-oxo)butylamino 6-(pyrrolidin-2,5-dion-1-yl) Afatinib |
|||
D291238 | Toronto Research Chemicals | 100mg | EUR 316 |
Des-(4-dimethylamino-2-en-1-oxo)butylamino 6-(5-Amino-pyrrolidin-2-on-1-yl) Afatinib |
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D291248 | Toronto Research Chemicals | 10mg | EUR 759 |
Des-(4-dimethylamino-2-en-1-oxo)butylamino 6-(5-Hydroxy-pyrrolidin-2-on-1-yl) Afatinib |
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D291245 | Toronto Research Chemicals | 10mg | EUR 874 |
Afamelanotide free base |
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330224 | MedKoo Biosciences | 1.0mg | EUR 265 |
I-37 free base( 2359690-13-2(free base)) |
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T8721L-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: I-37 free base( 2359690-13-2(free base)) |
I-37 free base( 2359690-13-2(free base)) |
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T8721L-1g | TargetMol Chemicals | 1g | Ask for price |
Description: I-37 free base( 2359690-13-2(free base)) |
I-37 free base( 2359690-13-2(free base)) |
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T8721L-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: I-37 free base( 2359690-13-2(free base)) |
I-37 free base( 2359690-13-2(free base)) |
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T8721L-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: I-37 free base( 2359690-13-2(free base)) |
I-37 free base( 2359690-13-2(free base)) |
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T8721L-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: I-37 free base( 2359690-13-2(free base)) |
I-37 free base (2359690-13-2(free base)) |
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MBS5759495-10mg | MyBiosource | 10mg | EUR 470 |
I-37 free base (2359690-13-2(free base)) |
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MBS5759495-1mg | MyBiosource | 1mg | EUR 210 |
I-37 free base (2359690-13-2(free base)) |
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MBS5759495-25mg | MyBiosource | 25mg | EUR 780 |
I-37 free base (2359690-13-2(free base)) |
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MBS5759495-50mg | MyBiosource | 50mg | EUR 1130 |
I-37 free base (2359690-13-2(free base)) |
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MBS5759495-5mg | MyBiosource | 5mg | EUR 335 |
EDC free base |
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GM6988 | Glentham Life Sciences | 5g | EUR 116.06 |
TMB free base |
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TB0954 | Bio Basic | 1g | EUR 85.06 |
S107 free base |
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530577 | MedKoo Biosciences | 100.0mg | EUR 750 |
THZ1 (Free base) |
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9664-25 | Biovision | each | EUR 1227.6 |
THZ1 (Free base) |
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9664-5 | Biovision | each | EUR 352.8 |
K201 free base |
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414202 | MedKoo Biosciences | 5.0mg | EUR 288 |
FIPI free base |
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407955 | MedKoo Biosciences | 200.0mg | EUR 1050 |
R406(free base) |
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E1KS1533 | EnoGene | 2mg | EUR 362.4 |
FIPI (free base) |
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B2372-25 | Biovision | each | EUR 757.2 |
FIPI (free base) |
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B2372-5 | Biovision | each | EUR 235.2 |
NG25 free base |
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562503 | MedKoo Biosciences | 5.0mg | EUR 485 |
R406 (free base) |
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A5880-100 | ApexBio | 100 mg | EUR 800 |
Description: Syk inhibitor |
R406 (free base) |
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A5880-25 | ApexBio | 25 mg | EUR 320 |
Description: Syk inhibitor |
R406 (free base) |
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A5880-5 | ApexBio | 5 mg | EUR 80 |
Description: Syk inhibitor |
R406 (free base) |
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A5880-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 148 |
Description: Syk inhibitor |
R406 (free base) |
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A5880-S | ApexBio | Evaluation Sample | EUR 22 |
Description: Syk inhibitor |
R406(free base) |
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MBS131267-100mg | MyBiosource | 100mg | EUR 1065 |
R406(free base) |
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MBS131267-500mg | MyBiosource | 500mg | EUR 2775 |
R406 (free base) |
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HY-11108 | MedChemExpress | 10mM/1mL | EUR 277.2 |
R406 free base |
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T2467-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: R406 free base |
R406 free base |
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T2467-1g | TargetMol Chemicals | 1g | Ask for price |
Description: R406 free base |
R406 free base |
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T2467-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: R406 free base |
R406 free base |
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T2467-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: R406 free base |
R406 free base |
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T2467-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: R406 free base |
SIS3 free base |
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T12923-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: SIS3 free base |
SIS3 free base |
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T12923-1g | TargetMol Chemicals | 1g | Ask for price |
Description: SIS3 free base |
SIS3 free base |
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T12923-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: SIS3 free base |
SIS3 free base |
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T12923-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: SIS3 free base |
SIS3 free base |
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T12923-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: SIS3 free base |
R406 (free base) |
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MBS8506526-2mg | MyBiosource | 2mg | EUR 440 |
R406 (free base) |
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MBS8506526-5x2mg | MyBiosource | 5x2mg | EUR 1835 |
R406 free base |
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MBS3606124-10mg | MyBiosource | 10mg | EUR 305 |
R406 free base |
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MBS3606124-25mg | MyBiosource | 25mg | EUR 405 |
R406 free base |
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MBS3606124-2mg | MyBiosource | 2mg | EUR 235 |
R406 free base |
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MBS3606124-50mg | MyBiosource | 50mg | EUR 620 |
R406 free base |
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MBS3606124-5mg | MyBiosource | 5mg | EUR 260 |
R788 free base |
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MBS3606474-10mg | MyBiosource | 10mg | EUR 315 |
R788 free base |
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MBS3606474-25mg | MyBiosource | 25mg | EUR 430 |
R788 free base |
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MBS3606474-2mg | MyBiosource | 2mg | EUR 225 |
R788 free base |
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MBS3606474-5mg | MyBiosource | 5mg | EUR 260 |
R788 free base |
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MBS3606474-5x25mg | MyBiosource | 5x25mg | EUR 1620 |
SIS3 free base |
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MBS5767611-5mg | MyBiosource | 5mg | EUR 915 |
SIS3 free base |
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MBS5767611-5x5mg | MyBiosource | 5x5mg | EUR 3970 |
SIS3 (free base) |
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HY-100444 | MedChemExpress | 10 mg | EUR 1244.61 |
Description: SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2[1]. |
ML355 free base |
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533249 | MedKoo Biosciences | 50.0mg | EUR 350 |
ML241 free base |
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406621 | MedKoo Biosciences | 10.0mg | EUR 90 |
MS023 free base |
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407274 | MedKoo Biosciences | 10.0mg | EUR 150 |
LYS01 free base |
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407398 | MedKoo Biosciences | 10.0mg | EUR 150 |
ML298 free base |
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407464 | MedKoo Biosciences | 5.0mg | EUR 240 |