Single cell transcriptomes reveal expression patterns of chemoreceptor genes

immusol

Melting dsDNA Donor Molecules Vastly Improves Precision Genome Enhancing in Caenorhabditiselegans

CRISPR genome modifying has revolutionized genetics in quite a few organisms. Contained in the nematode Caenorhabditiselegans one injection into every of the 2 gonad arms of an grownup hermaphrodite exposes tons of of meiotic germ cells to modifying mixtures, allowing the restoration of quite a lot of indels or small precision edits from every successfully injected animal. Sadly, significantly for extended insertions, modifying efficiencies can differ broadly, necessitating quite a lot of injections, and usually requiring co-selection methods.

Correct proper right here we present that melting double stranded DNA (dsDNA) donor molecules earlier to injection will enhance the frequency of tangible homology-directed restore (HDR) by quite a lot of fold for longer edits.

We describe troubleshooting methods that allow persistently excessive modifying efficiencies ensuing, as an illustration, in as lots as 100 unbiased GFP knock-ins from a single injected animal. These efficiencies make C. elegans by far the most effective metazoan to genome edit, eradicating limitations to the use and adoption of this facile system as a mannequin for understanding animal biology.

An embedded gene choice methodology utilizing knockoffs optimizing neural community

 Background: Gene alternative refers to find a small subset of discriminant genes from the gene expression profiles. The way in which to decide on genes that affect specific phenotypic traits efficiently is a crucial evaluation work throughout the topic of biology. The neural neighborhood has greater changing into functionality when dealing with nonlinear data, and it’ll most likely seize choices robotically and flexibly. On this work, we recommend an embedded gene alternative methodology using neural neighborhood.

The important genes could also be obtained by calculating the burden coefficient after the teaching is completed. In an effort to treatment the problem of black subject of neural neighborhood and extra make the teaching outcomes interpretable in neural neighborhood, we use the idea of knockoffs to assemble the knockoff attribute genes of the distinctive attribute genes. This system not solely make each attribute gene to compete with each other, however moreover make each attribute gene compete with its knockoff attribute gene. This methodology could assist to choose the vital factor genes that affect the decision-making of neural networks.

Outcomes: We use maize carotenoids, tocopherol methyltransferase, raffinose family oligosaccharides and human breast most cancers dataset to do verification and analysis.

Conclusions: The experiment outcomes show that the knockoffs optimizing neural neighborhood methodology has greater detection influence than the alternative current algorithms, and particularly for processing the nonlinear gene expression and phenotype data.

immusol
immusol

Fenretinide

9417-10
EUR 185

Fenretinide

9417-50
EUR 588

Single cell transcriptomes reveal expression patterns of chemoreceptor genes in olfactory sensory neurons of the Caribbean spiny lobster, Panulirus argus

Background: Crustaceans categorical various programs of receptor genes of their antennules, which house olfactory sensory neurons (OSNs) and non-olfactory chemosensory neurons. Transcriptomics analysis reveal that candidate chemoreceptor proteins embrace variant Ionotropic Receptors (IRs) along with every co-receptor IRs and tuning IRs, Transient Receptor Potential (TRP) channels, Gustatory Receptors, epithelial sodium channels, and class A G-protein coupled receptors (GPCRs). The Caribbean spiny lobster, Panulirus argus, expresses in its antennules nearly 600 IRs, 17 TRP channels, 1 Gustatory Receptor, 7 epithelial sodium channels, 81 GPCRs, 6 G proteins, and dozens of enzymes in signaling pathways.

Nonetheless, the exact combinatorial expression patterns of these proteins in single sensory neurons often are usually not acknowledged for any crustacean, limiting our understanding of how their chemosensory methods encode chemical top quality.

Outcomes: The aim of this analysis was to utilize transcriptomics to elucidate expression patterns of chemoreceptor genes in OSNs of P. argus. We generated and analyzed transcriptomes from 7 single OSNs, a couple of of which have been confirmed to reply a meals odor, along with an additional 7 multicell transcriptomes from preparations containing few (2-4), various (ca. 15), or many (ca. 400) OSNs.

We found that each OSN expressed the an identical 2 co-receptor IRs (IR25a, IR93a) nonetheless not the alternative 2 antennular coIRs (IR8a, IR76b), 9-53 tuning IRs nonetheless only one to some in extreme abundance, the an identical 5 TRP channels plus as a lot as 5 further TRPs, 12-17 GPCRs along with the an identical 5 expressed in every single cell transcriptome, the an identical Three G proteins plus others, many enzymes throughout the signaling pathways, nonetheless no Gustatory Receptors or epithelial sodium channels. The perfect distinction in receptor expression among the many many OSNs was the identification of the tuning IRs.

Conclusions: Our outcomes current an preliminary view of the combinatorial expression patterns of receptor molecules in single OSNs in a single species of decapod crustacean, along with receptors straight involved in olfactory transduction and others likely involved in modulation. Our outcomes moreover counsel variations in receptor expression in OSNs vs. totally different chemosensory neurons.

Camel Genetic Property Conservation by Tourism: A Key Sociocultural Methodology of Camelback Leisure Driving

  • Camels are distinctive elements, which can be comprised inside journey journey companies promoting ecotourism actions. Such recreations contribute to sustainable livelihoods for native communities and educational empowerment within the route of nature and its conservation.
  • At present, some native camel breeds’ survival reduces to this animal-based leisure enterprise and its reliability to hold out and promote custom-made corporations By conducting an on-site questionnaire to prospects collaborating in camelback driving excursions, we assessed the motivational elements affecting participation, satisfaction, and loyalty on this tourism section that can have made it socially differentiated.
  • The sixfold combination of staff effectivity, custom geography, quite a few and humane shut interaction, camel conduct and effectivity, sociotemporal context, and constructive earlier experience consists of the elemental dimensions that designate purchaser satisfaction and return intention likelihood inside this leisure enterprise.
  • Purchaser knowledge is essential for stakeholders to assemble personalised driving experiences and align earnings with environmental sustainability and biodiversity mainstream issues into their regularly operations. In flip, house camel vacationer rides could be managed as a viable path to nature conservation by serving to endangered native breeds to steer clear of their helpful devaluation and potential extinction.

gel casting base for evs3100

EVS3100-BASE ea
EUR 301

gel casting base for evs3200

EVS3200-BASE ea
EUR 301

gel casting base for evs3300

EVS3300-BASE ea
EUR 301

Ripasudil free base

HY-15685A 10mg
EUR 408

Masupirdine (free base)

HY-109118 1mg
EUR 223

R406 (free base)

HY-11108 10mM/1mL
EUR 231

ITI214 (free base)

HY-12501 100mg
EUR 2943

AS2863619 (free base)

HY-126675 5mg
EUR 1175

AZD3839 (free base)

HY-13438 50mg
EUR 1014

RPR107393 free base

HY-100299 1mg
EUR 481

FR167344 free base

HY-100301 1mg
EUR 2637

FR183998 free base

HY-100302 1mg
EUR 1127

FR194738 free base

HY-100303 1mg
EUR 1990

Vatalanib (free base)

HY-10203 5mg
EUR 119

YM158 (free base)

HY-U00355 1mg
EUR 2309

R406(free base)

E1KS1533 2mg
EUR 521

TMB free base

TB0954 1g
EUR 70.88

AZD4547, Free Base

ADC-P-063 unit Ask for price

AZD8055, Free Base

ADC-P-064 unit Ask for price

Cyclopamine, Free Base

ADC-P-079 unit Ask for price

Ixabepilone, Free Base

ADC-P-104 unit Ask for price

Xylazine (free base)

Q-1445.0025 25.0g
EUR 321
Description: Sum Formula: C12H16N2S; CAS# [7361-61-7]

R406 (free base)

A5880-100 100 mg
EUR 1210
Description: R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins.

R406 (free base)

A5880-25 25 mg
EUR 514
Description: R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins.

R406 (free base)

A5880-5 5 mg
EUR 166
Description: R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins.

R406 (free base)

A5880-5.1 10 mM (in 1mL DMSO)
EUR 264
Description: R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins.

R406 (free base)

A5880-S Evaluation Sample
EUR 81
Description: R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins.

Rucaparib (free base)

A8893-10 10 mg
EUR 200
Description: Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway.

Rucaparib (free base)

A8893-200 200 mg
EUR 1036
Description: Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway.

Rucaparib (free base)

A8893-5 5 mg
EUR 137
Description: Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway.

Rucaparib (free base)

A8893-5.1 10 mM (in 1mL DMSO)
EUR 142
Description: Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway.

Rucaparib (free base)

A8893-50 50 mg
EUR 456
Description: Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway.

LY2835219 free base

A3575-100 100 mg
EUR 572
Description: LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity.

LY2835219 free base

A3575-25 25 mg
EUR 258
Description: LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity.

LY2835219 free base

A3575-5 5 mg
EUR 142
Description: LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity.

Ruxolitinib (free base)

10-042 25 mg
EUR 348.5
Description: Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50=322nM). Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro. It is investigated against the spread of the SARS-CoV-2 (COVID-19).

MCC950 (Free base)

B1031-1
EUR 153

MCC950 (Free base)

B1031-5
EUR 457

Apatinib (Free base)

B1613-25
EUR 414

Apatinib (Free base)

B1613-5
EUR 142

Carubicin (Free base)

B1853-1
EUR 153

Carubicin (Free base)

B1853-5
EUR 457

Anlotinib, free base

B2156-25
EUR 588

Anlotinib, free base

B2156-5
EUR 185

FIPI (free base)

B2372-25
EUR 631

FIPI (free base)

B2372-5
EUR 196

Terbinafine (Free base)

B2423-250
EUR 207

Terbinafine (Free base)

B2423-50
EUR 120

PLX5622 (free base)

B2965-25 25 mg
EUR 753

PLX5622 (free base)

B2965-5 5 mg
EUR 227

THZ1 (Free base)

9664-25
EUR 1023

THZ1 (Free base)

9664-5
EUR 294

Vatalanib, Free Base

2026-25
EUR 305

Vatalanib, Free Base

2026-5
EUR 126

Erlotinib, Free Base

2048-100
EUR 158

Erlotinib, Free Base

2048-1000
EUR 387

Sunitinib, Free base

2097-100
EUR 191

Sunitinib, Free base

2097-1000
EUR 501

Sunitinib, Free base

2097-25
EUR 115

Lapatinib, Free base

2138-100
EUR 387

Lapatinib, Free base

2138-25
EUR 191

Ruxolitinib, Free base

2139-100 Ask for price

Ruxolitinib, Free base

2139-25
EUR 533

Ruxolitinib, Free base

2139-5
EUR 207

Imatinib, Free base

2141-100
EUR 147

Imatinib, Free base

2141-1000
EUR 419

Linsitinib, Free base

2294-25
EUR 566

Linsitinib, Free base

2294-5
EUR 185

Tipifarnib, Free base

2296-1
EUR 142

Tipifarnib, Free base

2296-5
EUR 414

JTV-519 (free base)

HY-15293A 5mg
EUR 567

RGB-286638 (free base)

HY-15504A 100mg
EUR 2804

DOV-216,303 (Free Base)

HY-18332C 10mM/1mL
EUR 492

SB-334867 (free base)

HY-10895A 10mg
EUR 215

SNT-207858 (free base)

HY-11030A 10mg
EUR 911

APX-115 (free base)

HY-120801A 5mg
EUR 223

LY-2584702 (free base)

HY-12493 5mg
EUR 165

Genz-123346 (free base)

HY-12744 10mM/1mL
EUR 189

YHO-13351 (free base)

HY-12758A 10mM/1mL
EUR 176

FK-448 Free base

HY-100193 10mg
EUR 1887

KW-8232 free base

HY-100304 10mg
EUR 5018

YM-53601 free base

HY-100313 1mg
EUR 1559

AV-412 (free base)

HY-10346A 5mg
EUR 173

CP-319340(free base)

HY-U00270 5mg
EUR 877

Staurosporine, >99% Free Base

BC090-001 1mg
EUR 246

Staurosporine, >99% Free Base

BC090-005 5mg
EUR 340

Vandetanib, >99% Free Base

BC098-025 25mg
EUR 232

Vandetanib, >99% Free Base

BC098-050 50mg
EUR 286

Vandetanib, >99% Free Base

BC098-100 100mg
EUR 313

Vandetanib, >100% Free Base

BC098-500 500mg
EUR 658

L-Arginine free base

AB0205 100g
EUR 63.15

Z-NHNH2 (free base)

Q-1150.0025 25.0g
EUR 126
Description: Sum Formula: C8H10N2O2; CAS# [5331-43-1]

Z-NHNH2 (free base)

Q-1150.0100 100.0g
EUR 321
Description: Sum Formula: C8H10N2O2; CAS# [5331-43-1]

SB-334867 free base

B3423-100 100 mg
EUR 599
Description: SB-334867 free base is a selective antagonist of orexin-1 receptor [1].Orexin-A and orexin-B are two peptides isolated from rat hypothalamus. They are involved in some physiological functions such as the control of feeding, energy metabolism and regulation of the sleep-wake cycle.

SB-334867 free base

B3423-25 25 mg
EUR 290
Description: SB-334867 free base is a selective antagonist of orexin-1 receptor [1].Orexin-A and orexin-B are two peptides isolated from rat hypothalamus. They are involved in some physiological functions such as the control of feeding, energy metabolism and regulation of the sleep-wake cycle.

SB-334867 free base

B3423-5 5 mg
EUR 128
Description: SB-334867 free base is a selective antagonist of orexin-1 receptor [1].Orexin-A and orexin-B are two peptides isolated from rat hypothalamus. They are involved in some physiological functions such as the control of feeding, energy metabolism and regulation of the sleep-wake cycle.

SB-334867 free base

B3423-5.1 10 mM (in 1mL DMSO)
EUR 131
Description: SB-334867 free base is a selective antagonist of orexin-1 receptor [1].Orexin-A and orexin-B are two peptides isolated from rat hypothalamus. They are involved in some physiological functions such as the control of feeding, energy metabolism and regulation of the sleep-wake cycle.

BMS-345541(free base)

B4655-10 10 mg
EUR 235
Description: BMS-345541(free base) is a selective inhibitor of IKK-1 and IKK-2 with IC50 value of 4?M and 0.3?M, respectively [1].IKK is also known as nuclear factor kappa-B kinase subunit inhibitor and involves in cytokine-activated intracellular signaling pathways.

BMS-345541(free base)

B4655-5 5 mg
EUR 171
Description: BMS-345541(free base) is a selective inhibitor of IKK-1 and IKK-2 with IC50 value of 4?M and 0.3?M, respectively [1].IKK is also known as nuclear factor kappa-B kinase subunit inhibitor and involves in cytokine-activated intracellular signaling pathways.

BMS-345541(free base)

B4655-50 50 mg
EUR 595
Description: BMS-345541(free base) is a selective inhibitor of IKK-1 and IKK-2 with IC50 value of 4?M and 0.3?M, respectively [1].IKK is also known as nuclear factor kappa-B kinase subunit inhibitor and involves in cytokine-activated intracellular signaling pathways.

GSK J4 free base

B5959-10 10 mg
EUR 373
Description: GSK J4 free base

GSK J4 free base

B5959-50 50 mg
EUR 1198
Description: GSK J4 free base

AM-095 free base

A3167-10 10 mg
EUR 212
Description: AM095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (LPA1) with IC50 values of 0.73 and 0.98 ?M for mouse or recombinant human LPA1, respectively [1].

AM-095 free base

A3167-100 100 mg
EUR 804
Description: AM095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (LPA1) with IC50 values of 0.73 and 0.98 ?M for mouse or recombinant human LPA1, respectively [1].

AM-095 free base

A3167-200 200 mg
EUR 1152
Description: AM095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (LPA1) with IC50 values of 0.73 and 0.98 ?M for mouse or recombinant human LPA1, respectively [1].

AM-095 free base

A3167-5 5 mg
EUR 166
Description: AM095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (LPA1) with IC50 values of 0.73 and 0.98 ?M for mouse or recombinant human LPA1, respectively [1].

AM-095 free base

A3167-50 50 mg
EUR 572
Description: AM095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (LPA1) with IC50 values of 0.73 and 0.98 ?M for mouse or recombinant human LPA1, respectively [1].

SGI-1776 free base

A4192-10 10 mg
EUR 247
Description: SGI-1776 free base, N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival.

SGI-1776 free base

A4192-5 5 mg
EUR 154
Description: SGI-1776 free base, N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival.

SGI-1776 free base

A4192-5.1 10 mM (in 1mL DMSO)
EUR 166
Description: SGI-1776 free base, N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival.

SGI-1776 free base

A4192-50 50 mg
EUR 525
Description: SGI-1776 free base, N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival.

SGI-1776 free base

A4192-S Evaluation Sample
EUR 81
Description: SGI-1776 free base, N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival.

BMS-345541 (Free base)

B1907-1
EUR 142

BMS-345541 (Free base)

B1907-5
EUR 414

UNC-926, free base

B2158-25
EUR 631

UNC-926, free base

B2158-5
EUR 196

StemRegenin 1, Free base

2642-1
EUR 131

StemRegenin 1, Free base

2642-5
EUR 332

GSK-J4 (Free base)

2762-1
EUR 120

GSK-J4 (Free base)

2762-5
EUR 262

RGB-286638,  free base

2886-25
EUR 756

RGB-286638,  free base

2886-5
EUR 229

Afatinib

HY-10261 200mg
EUR 312

Afatinib

A170-100MG 100mg
EUR 102

Glyoxalase I inhibitor (free base)

HY-15167A 50mg
EUR 2530

Bay 65-1942 (free base)

HY-50949 10mg
EUR 1069

Gastrofensin AN 5 free base

HY-100296 5mg
EUR 2120

SB 202190, >99% Free Base

BC086-025 25mg
EUR 205

SB 202190, >99% Free Base

BC086-050 50mg
EUR 246

SB 203580, >99% Free Base

BC087-025 25mg
EUR 219

SB 203580, >99% Free Base

BC087-050 50mg
EUR 286

Biotin ethylenediamine (free base form)

90071 25MG
EUR 132
Description: Minimum order quantity: 1 unit of 25MG

biotin cadaverine, free base form

90079 50MG
EUR 215
Description: Minimum order quantity: 1 unit of 50MG

H-Tyr-OEt (free base)

E-2900.0025 25.0g
EUR 139
Description: Sum Formula: C11H15NO3; CAS# [949-67-7]

H-Tyr-OEt (free base)

E-2900.0100 100.0g
EUR 357
Description: Sum Formula: C11H15NO3; CAS# [949-67-7]

BAY 43-9006, Free base

2142-100
EUR 419

BAY 43-9006, Free base

2142-25
EUR 169

BAY 58-2667 (Free base)

2452-1
EUR 354

BAY 58-2667 (Free base)

2452-5
EUR 1132

EZSolution? StemRegenin 1, Free base

2643-1
EUR 142

Afatinib (dimaleate)

HY-10261A 200mg
EUR 312

Afatinib (BIBW2992)

A8247-10 10 mg
EUR 221
Description: Afatinib (BIBW2992), an irreversible inhibitor of the ErbB family of tyrosine kinases, downregulates ErbB signalling by binding to the kinase domains of epidermal growth factor receptor (EGFR)/ human epidermal growth factor receptor 2 (HER2) with IC50 of 0.5 nM and 14nM, respectively.

Afatinib (BIBW2992)

A8247-5 5 mg
EUR 147
Description: Afatinib (BIBW2992), an irreversible inhibitor of the ErbB family of tyrosine kinases, downregulates ErbB signalling by binding to the kinase domains of epidermal growth factor receptor (EGFR)/ human epidermal growth factor receptor 2 (HER2) with IC50 of 0.5 nM and 14nM, respectively.

Afatinib (BIBW2992)

A8247-5.1 10 mM (in 1mL DMSO)
EUR 244
Description: Afatinib (BIBW2992), an irreversible inhibitor of the ErbB family of tyrosine kinases, downregulates ErbB signalling by binding to the kinase domains of epidermal growth factor receptor (EGFR)/ human epidermal growth factor receptor 2 (HER2) with IC50 of 0.5 nM and 14nM, respectively.

Afatinib (BIBW2992)

A8247-50 50 mg
EUR 512
Description: Afatinib (BIBW2992), an irreversible inhibitor of the ErbB family of tyrosine kinases, downregulates ErbB signalling by binding to the kinase domains of epidermal growth factor receptor (EGFR)/ human epidermal growth factor receptor 2 (HER2) with IC50 of 0.5 nM and 14nM, respectively.

Afatinib (BIBW2992)

A8247-S Evaluation Sample
EUR 81
Description: Afatinib (BIBW2992), an irreversible inhibitor of the ErbB family of tyrosine kinases, downregulates ErbB signalling by binding to the kinase domains of epidermal growth factor receptor (EGFR)/ human epidermal growth factor receptor 2 (HER2) with IC50 of 0.5 nM and 14nM, respectively.

Afatinib dimaleate

A3145-10 10 mg
EUR 221
Description: Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

Afatinib dimaleate

A3145-5 5 mg
EUR 147
Description: Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

Afatinib dimaleate

A3145-5.1 10 mM (in 1mL DMSO)
EUR 119
Description: Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

Afatinib dimaleate

A3145-50 50 mg
EUR 512
Description: Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

Human Free PSA (f-PSA) ELISA Kit

PRB-5049-FREE 96 assays
EUR 572

PNU-282987 (S enantiomer free base)

HY-12560D 5mg
EUR 1014

Cyclosporin A-Derivative 1 (Free base)

HY-P1355A 1mg
EUR 223

biotin-x cadaverine, free base form

90080 20MG
EUR 215
Description: Minimum order quantity: 1 unit of 20MG

H-Arg(Mtr)-OtBu (free base)

E-3075.0001 1.0g
EUR 309
Description: Sum Formula: C20H34N4O5S; CAS# [115608-61-2]

H-Arg(Mtr)-OtBu (free base)

E-3075.0005 5.0g
EUR 1143
Description: Sum Formula: C20H34N4O5S; CAS# [115608-61-2]

H-Arg(Pmc)-OtBu (free base)

E-3085.0001 1.0g
EUR 418
Description: Sum Formula: C24H40N4O5S; CAS# [169543-81-1]

H-Arg(Pmc)-OtBu (free base)

E-3085.0005 5.0g
EUR 1554
Description: Sum Formula: C24H40N4O5S; CAS# [169543-81-1]

CHIR 99021, GSK-3 Inhibitor , Free Base

BC212-002 2 mg
EUR 178

CHIR 99021, GSK-3 Inhibitor , Free Base

BC212-005 5 mg
EUR 265

CHIR 99021, GSK-3 Inhibitor , Free Base

BC212-010 10 mg
EUR 315

CHIR 99021, GSK-3 Inhibitor , Free Base

BC212-025 25 mg
EUR 394

CHIR 99021, GSK-3 Inhibitor , Free Base

BC212-100 100 mg
EUR 887

H-Ala-Ala-Phe-AMC (free base)

I-1415.0050 50.0mg
EUR 151
Description: Sum Formula: C25H28N4O5; CAS# [62037-41-6]

H-Ala-Ala-Phe-AMC (free base)

I-1415.0250 250.0mg
EUR 515
Description: Sum Formula: C25H28N4O5; CAS# [62037-41-6]

Human Free PSA (f-PSA) ELISA Kit

PRB-5049-FREE-5 5 x 96 assays
EUR 2283

(D-Ser(tBu)6,Azagly10)-LHRH (free base)

H-7296.0005 5.0mg
EUR 183
Description: Sum Formula: C59H84N18O14; CAS# [65807-02-5]

(D-Ser(tBu)6,Azagly10)-LHRH (free base)

H-7296.0025 25.0mg
EUR 641
Description: Sum Formula: C59H84N18O14; CAS# [65807-02-5]

casting base

EHS3100-CAST ea
EUR 107

casting base

EHS3200-CAST ea
EUR 124

casting base

EHS3300-CAST ea
EUR 124

Tetracycline base

GA9779-100G 100 g
EUR 150

Tetracycline base

GA9779-10G 10 g
EUR 46

Tetracycline base

GA9779-25G 25 g
EUR 62

Rimonabant base

GX9120-10MG 10 mg
EUR 86

Rimonabant base

GX9120-25MG 25 mg
EUR 130

Tris-base

20-abx082498
  • EUR 328.00
  • EUR 203.00
  • EUR 411.00
  • 1 kg
  • 500 g
  • 5 kg

Vincamine base

Q-1435.0005 5.0g
EUR 225
Description: Sum Formula: C21H26N2O3; CAS# [1617-90-9]

Vincamine base

Q-1435.0025 25.0g
EUR 803
Description: Sum Formula: C21H26N2O3; CAS# [1617-90-9]

ProteoIQ Base

PS2 1
EUR 4262

Fuchsine base (monohydrochloride)

HY-B1539A 1g
EUR 119

Bisindolylmaleimide I base

GL2668-1MG 1 mg
EUR 137

Bisindolylmaleimide I base

GL2668-5MG 5 mg
EUR 269

BIX 01294 base

GL8747-1MG 1 mg
EUR 106

BIX 01294 base

GL8747-25MG 25 mg
EUR 409

BIX 01294 base

GL8747-5MG 5 mg
EUR 182

Related articles

immusol

genome-scale fashions to optimize nutrient present for sustained algal progress

Using genome-scale fashions to optimize nutrient current for sustained algal progress and lipid productiveness Nutrient availability is essential for progress of algae and completely totally different microbes used for producing worthwhile biochemical merchandise. Figuring out the optimum ranges of nutrient presents to cultures can eradicate feeding of further dietary nutritional vitamins, lowering manufacturing prices and […]

Learn More
immusol

Affiliation evaluation of the surfactant protein-C gene

The Full Chloroplast Genome of Arabidopsis thaliana Remoted in Korea (Brassicaceae): An Investigation of Intraspecific Variations of the Chloroplast Genome of Korean A. thaliana Arabidopsis thaliana (L.) Heynh. is a mannequin organism of plant molecular biology. Greater than 1,700 full genome sequences have been sequenced, nonetheless no Korean isolate genomes have been sequenced up to […]

Learn More
immusol

Next generation sequencing reveals a novel pathogenic variant in the ATMgene

Water-Pipe Smoking Publicity Deregulates a Set of Genes Related to Human Head and Neck Most cancers Growth and Prognosis Water-pipe smoking (WPS) is popping into most likely essentially the most well-liked kind of tobacco use among the many many many youth, notably contained in the Coronary heart East, altering cigarettes quickly and turning into a […]

Learn More

Leave a Reply

Your email address will not be published.